581780-77-0Relevant academic research and scientific papers
Synthesis and evaluation of a novel series of farnesyl protein transferase inhibitors as non-peptidic CAAX tetrapeptide analogues
Perez, Michel,Maraval, Catherine,Dumond, Stephan,Lamothe, Marie,Schambel, Philippe,Etievant, Chantal,Hill, Bridget
, p. 1455 - 1458 (2003)
A novel series of compounds, derived from 4-amino-phenyl piperazine, has been designed to selectively inhibit farnesyl protein transferase (FPTase) as CAAX tetrapeptide analogues. Certain of these compounds were shown to possess low nanomolar inhibitory a
