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Idebenone
Cas No: 58186-27-9
USD $ 900.0-950.0 / Kilogram 1 Kilogram 1 Kilogram/Day DB BIOTECH CO., LTD Contact Supplier
High Quality 99% Idebenone Powder CAS NO.58186-27-9
Cas No: 58186-27-9
USD $ 30.0-50.0 / Kilogram 1 Kilogram 500 Kilogram/Month Mike(Wuhan) Biotechnology Co.,Ltd Contact Supplier
High Quality 99% Idebenone Powder
Cas No: 58186-27-9
USD $ 1.0-2.0 / Gram 10 Gram 10 Metric Ton/Month Shaanxi Greenyo Biotech Co., Ltd. Contact Supplier
China supplier Idebenone
Cas No: 58186-27-9
USD $ 1000.0-1750.0 / Kilogram 1 Kilogram 200 Metric Ton/Year Hangzhou Sartort Biopharma Co., Ltd Contact Supplier
Idebenone powder 58186-27-9 Idevenone
Cas No: 58186-27-9
USD $ 1480.0-1480.0 / Kilogram 1 Kilogram 5000 Kilogram/Month ShangHai Soyoung Biotechnology Inc Contact Supplier
Idebenone
Cas No: 58186-27-9
No Data 100 Gram 50 Kilogram/Week Xi'an Yinherb Bio-Tech Co., Ltd. Contact Supplier
Pharmaceutical CAS 58186-27-9 Antioxidant Idebenone Nootropics Idebenone Powder Idebenone
Cas No: 58186-27-9
USD $ 0.02-0.03 / Gram 1 Gram 6000 Metric Ton/Day Wuhan Kanal Technology Co., Ltd. Contact Supplier
Idebenone CAS58186-27-9
Cas No: 58186-27-9
USD $ 1100.0-1360.0 / Kilogram 1 Kilogram 500 Kilogram/Week Kono Chem Co.,Ltd Contact Supplier
Idebenone
Cas No: 58186-27-9
USD $ 480.0-480.0 / Kilogram 1 Kilogram 1 Metric Ton/Year Sinoway Industrial Co., Ltd. Contact Supplier
High quality Idebenone supplier in China
Cas No: 58186-27-9
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier

58186-27-9 Usage

References

https://en.wikipedia.org/wiki/Idebenone http://www.webmd.com/vitamins-supplements/ingredientmono-1078-idebenone.aspx?activeingredientid=1078&activeingredientname=idebenone

Uses

Ubiquinone derivative with protective effects against cerebral ischemia. Nootropic

Description

Idebenone is an organic compound belonging to the quinone family, being similar to coenzyme Q-10. It is a kind of drug developed by Takeda Pharmaceutical Company for the treatment of Alzheimer’s disease and some other cognitive defects. However, these have been not very much progress associated with this indication. It is now also used for the treatment of Friedreich’s ataxia with a positive effect on cardiac hypertrophy and neurological function. However, this indication is only approved in Canada, not in Europe and US. It is now under investigation on its efficacy for the treatment of Duchenne muscular dystrophy, Leber’s hereditary optic neuropathy, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) as well as primary progressive multiple sclerosis. The efficacy of this drug still demands more evidences.

Brand name

AVAN

Originator

Takeda (Japan)

Uses

idebenone is an anti-oxidant capable of protecting the skin from a variety of free-radical attacks, including the formation of secondary chemicals that negatively affect skin physiology. It is said to improve intrinsic as well as extrinsic skin damage caused by freeradical formation. Idebenone is a synthetically manufactured form of coenzyme Q10 and has a smaller molecular structure. This allows it to penetrate the skin and apparently the cellular membrane. Clinical studies demonstrate a visible improvement in photodamaged skin, reduced skin roughness and dryness, decreased fine lines and wrinkles, and increased skin hydration. In addition, idebenone helps improve hyperpigmentation because its molecular structure is similar to that of hydroquinone. Although most of the associated benefits are seen primarily in the epidermis, some increase in dermal collagen has also been confirmed. Idebenone has been used for such health-related problems as Alzheimer’s and heart disease.

Biological Activity

Antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo . Inhibits apoptosis of astrocytes via increased NGF production.

Definition

ChEBI: A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits ere modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.

Description

Idebenone is a structural relative of ubiquinone (Coenzyme Q10) that protects the CNS from the effects of ischemia via improving brain metabolism. It is reported to be of potential use in the management of patients with cerebral apoplexy, cerebral arteriosclerosis and related disorders.

Uses

cognition enhancer, nootropic

Chemical Properties

Yellow-Orange Crystalline Solid

Uses

chemotherapy drug
InChI:InChI=1/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3

58186-27-9 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (I0848)  Idebenone  >98.0%(HPLC)(T) 58186-27-9 1g 690.00CNY Detail
TCI America (I0848)  Idebenone  >98.0%(HPLC)(T) 58186-27-9 5g 1,490.00CNY Detail
TCI America (I0848)  Idebenone  >98.0%(HPLC)(T) 58186-27-9 25g 3,990.00CNY Detail
Sigma-Aldrich (67805)  Idevenone  analytical standard 58186-27-9 67805-10MG 616.59CNY Detail

58186-27-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name idebenone

1.2 Other means of identification

Product number -
Other names Idebenone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:58186-27-9 SDS

58186-27-9Synthetic route

10-(2,3,4-trimethoxy-6-methylphenyl)decan-1-ol
1286209-74-2

10-(2,3,4-trimethoxy-6-methylphenyl)decan-1-ol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
With ammonium peroxydisulfate; nitric acid In water; acetone at 50℃; for 2.16h;98%
Multi-step reaction with 3 steps
1: iodine / 1 h / 25 °C
2: dihydrogen peroxide; toluene-4-sulfonic acid / acetic acid / 0.42 h / 75 °C
3: sodium carbonate / methanol; water / 20 h / 25 °C
View Scheme
disodium nitrosodisulfonate

disodium nitrosodisulfonate

6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol
77712-29-9

6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
In methanol; water96.9%
6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol
77712-29-9

6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
With oxygen; salcomine In N,N-dimethyl-formamide for 72h; Ambient temperature;87%
With potassium nitrososulfonate In sodium hydroxide for 1h; Ambient temperature;67%
With oxygen; salcomine In N,N-dimethyl-formamide Quantum yield; Ambient temperature; reaction time, additive;
2,3-dimethoxy-6-methyl-5-benzyloxydecyl-p-benzoquinone
1251831-79-4

2,3-dimethoxy-6-methyl-5-benzyloxydecyl-p-benzoquinone

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Stage #1: 2,3-dimethoxy-6-methyl-5-benzyloxydecyl-p-benzoquinone With palladium 10% on activated carbon; hydrogen In methanol at 23℃; for 24h;
Stage #2: With palladium 10% on activated carbon; oxygen In methanol at 23℃; for 24h;
82%
2,3-dimethoxy-5-methyl-6-(10'-acetoxydecyl)-1,4-benzoquinone
58186-28-0

2,3-dimethoxy-5-methyl-6-(10'-acetoxydecyl)-1,4-benzoquinone

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
With sodium carbonate In methanol; water at 25℃; for 20h;80%
With water; sodium carbonate In methanol at 0℃; for 36h;61%
With hydrogenchloride; sodium chloride In methanol
11-hydroxyundecanoic acid
3669-80-5

11-hydroxyundecanoic acid

2,3-Dimethoxy-5-methyl-1,4-benzoquinone
605-94-7

2,3-Dimethoxy-5-methyl-1,4-benzoquinone

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
With dihydrogen peroxide; oxygen In water; acetone at 75℃; Catalytic behavior; Reagent/catalyst; Temperature;80%
With dipotassium peroxodisulfate; oxygen; silver nitrate In water; acetonitrile at 80℃; for 4h; Catalytic behavior; Reagent/catalyst; Solvent;80%
With dipotassium peroxodisulfate; silver nitrate In water; acetonitrile at 80℃; for 4h;75%
Stage #1: 11-hydroxyundecanoic acid; 2,3-Dimethoxy-5-methyl-1,4-benzoquinone With silver nitrate In water; acetonitrile
Stage #2: With dipotassium peroxodisulfate In water; acetonitrile at 75℃; for 3h; Solvent; Reagent/catalyst;
65%
C19H30O5

C19H30O5

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Stage #1: C19H30O5 With dipotassium hydrogenphosphate; potassium hydroxylamine-N,N-disulphonate In N,N-dimethyl-formamide at 50℃; for 8h;
Stage #2: With hydrogenchloride In ethanol; N,N-dimethyl-formamide at 50℃; for 8h;
Stage #3: With lithium aluminium tetrahydride In N,N-dimethyl-formamide at 80℃; for 3h;
63%
2,3-dimethoxy-5-methyl-6-(9'-methoxycarbonylnonyl)-1,4-benzoquinone
58186-02-0

2,3-dimethoxy-5-methyl-6-(9'-methoxycarbonylnonyl)-1,4-benzoquinone

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
(i) LiAlH4, (ii) aq. FeCl3; Multistep reaction;
ester of 6-(9-carboxynonyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone

ester of 6-(9-carboxynonyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
With lithium aluminium tetrahydride; iron(III) chloride 1.) diethyl ether, RT, 1 h, 2.) diethyl ether; Yield given. Multistep reaction;
methyl 10-chloro-10-oxodecanoate
14065-32-8

methyl 10-chloro-10-oxodecanoate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 71 percent / AlCl3 / CH2Cl2 / 24 h / Heating
2: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C
3: 96 percent / Et3N; DMAP / CH2Cl2 / 7 h / 20 °C
4: 49 percent / LiBr / dimethylformamide / 24 h / 120 °C
5: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
6: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
7: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
sebacic acid mono methyl ester
818-88-2

sebacic acid mono methyl ester

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: thionyl chloride
2: 71 percent / AlCl3 / CH2Cl2 / 24 h / Heating
3: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C
4: 96 percent / Et3N; DMAP / CH2Cl2 / 7 h / 20 °C
5: 49 percent / LiBr / dimethylformamide / 24 h / 120 °C
6: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
7: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
8: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
1-(2,3,4,5-tetramethoxy-6-methylphenyl)-1,10-decenediol
374622-25-0

1-(2,3,4,5-tetramethoxy-6-methylphenyl)-1,10-decenediol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 96 percent / Et3N; DMAP / CH2Cl2 / 7 h / 20 °C
2: 49 percent / LiBr / dimethylformamide / 24 h / 120 °C
3: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
4: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
5: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
methyl 10-(2,3,4,5-tetramethoxy-6-methylphenyl)-10-undecenoate
374622-17-0

methyl 10-(2,3,4,5-tetramethoxy-6-methylphenyl)-10-undecenoate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 92 percent / LiAlH4 / tetrahydrofuran / 1 h / 0 °C
2: 96 percent / Et3N; DMAP / CH2Cl2 / 7 h / 20 °C
3: 49 percent / LiBr / dimethylformamide / 24 h / 120 °C
4: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
5: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
6: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
10-(2,3,4,5-tetramethoxy-6-methylphenyl)-9-decenylacetate

10-(2,3,4,5-tetramethoxy-6-methylphenyl)-9-decenylacetate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
2: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
3: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
10-(2,3,4,5-tetramethoxy-6-methylphenyl)decylacetate
374622-20-5

10-(2,3,4,5-tetramethoxy-6-methylphenyl)decylacetate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
2: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
10-methylcarbonyloxy-1-(2,3,4,5-tetramethoxy-6-methylphenyl)decylacetate
374622-18-1

10-methylcarbonyloxy-1-(2,3,4,5-tetramethoxy-6-methylphenyl)decylacetate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 49 percent / LiBr / dimethylformamide / 24 h / 120 °C
2: 99 percent / H2 / Pd/C / methanol / 1 h / 20 °C
3: 88 percent / CAN / acetonitrile; H2O / 0.25 h / 0 °C
4: 61 percent / Na2CO3; H2O / methanol / 36 h / 0 °C
View Scheme
methyl 10-(2'-hydroxy-3',4'-dimethoxy-6'-methylphenyl)decanoate
58185-89-0

methyl 10-(2'-hydroxy-3',4'-dimethoxy-6'-methylphenyl)decanoate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4 / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature
2: 67 percent / ON(SO3K)2 / aq. NaOH / 1 h / Ambient temperature
View Scheme
methyl 9-(2'-hydroxy-3',4'-dimethoxy-6'-methylbenzoyl)nonanoate
58185-88-9

methyl 9-(2'-hydroxy-3',4'-dimethoxy-6'-methylbenzoyl)nonanoate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) NaBH4, 2.) H2 / 2.) Pd/C
2: LiAlH4 / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature
3: 67 percent / ON(SO3K)2 / aq. NaOH / 1 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: potassium dihydrogenphosphate; potassium nitrososulfonate
2: (i) LiAlH4, (ii) aq. FeCl3
View Scheme
9-bromononan-1-ol
55362-80-6

9-bromononan-1-ol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 9 steps
2: 95 percent / dimethylsulfoxide / 15 h / 80 °C
3: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
4: PCl5 / CH2Cl2 / 2 h / 25 °C
5: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
6: 79 percent / NaOH / methanol / 2 h / Ambient temperature
7: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
8: NaOH / methanol / 24 h / 5 °C
9: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 9 steps
2: 95 percent / dimethylsulfoxide / 15 h / 80 °C
3: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
4: PCl5 / CH2Cl2 / 2 h / 25 °C
5: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
6: 79 percent / NaOH / methanol / 2 h / Ambient temperature
7: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
8: NaOH / methanol / 24 h / 5 °C
9: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 9 steps
2: 95 percent / dimethylsulfoxide / 15 h / 80 °C
3: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
4: PCl5 / CH2Cl2 / 2 h / 25 °C
5: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
6: 79 percent / NaOH / methanol / 2 h / Ambient temperature
7: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
8: NaOH / methanol / 24 h / 5 °C
9: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 9 steps
2: 95 percent / dimethylsulfoxide / 15 h / 80 °C
3: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
4: PCl5 / CH2Cl2 / 2 h / 25 °C
5: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
6: 79 percent / NaOH / methanol / 2 h / Ambient temperature
7: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
8: NaOH / methanol / 24 h / 5 °C
9: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
9-bromononyl acetate
53596-82-0

9-bromononyl acetate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 95 percent / dimethylsulfoxide / 15 h / 80 °C
2: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
3: PCl5 / CH2Cl2 / 2 h / 25 °C
4: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
5: 79 percent / NaOH / methanol / 2 h / Ambient temperature
6: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
7: NaOH / methanol / 24 h / 5 °C
8: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 8 steps
1: 95 percent / dimethylsulfoxide / 15 h / 80 °C
2: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
3: PCl5 / CH2Cl2 / 2 h / 25 °C
4: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
5: 79 percent / NaOH / methanol / 2 h / Ambient temperature
6: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
7: NaOH / methanol / 24 h / 5 °C
8: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 8 steps
1: 95 percent / dimethylsulfoxide / 15 h / 80 °C
2: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
3: PCl5 / CH2Cl2 / 2 h / 25 °C
4: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
5: 79 percent / NaOH / methanol / 2 h / Ambient temperature
6: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
7: NaOH / methanol / 24 h / 5 °C
8: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 8 steps
1: 95 percent / dimethylsulfoxide / 15 h / 80 °C
2: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
3: PCl5 / CH2Cl2 / 2 h / 25 °C
4: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
5: 79 percent / NaOH / methanol / 2 h / Ambient temperature
6: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
7: NaOH / methanol / 24 h / 5 °C
8: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
methyl 10-hydroxydecanoate
2640-94-0

methyl 10-hydroxydecanoate

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) NaOH / p-TsOH / 1.) MeOH, reflux, 3 h; 2.) 60 degC, 2 h
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 1.) NaOH / p-TsOH / 1.) MeOH, reflux, 3 h; 2.) 60 degC, 2 h
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 1.) NaOH / p-TsOH / 1.) MeOH, reflux, 3 h; 2.) 60 degC, 2 h
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 1.) NaOH / p-TsOH / 1.) MeOH, reflux, 3 h; 2.) 60 degC, 2 h
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
10-acetoxydecanoic acid
92038-37-4

10-acetoxydecanoic acid

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: PCl5 / CH2Cl2 / 2 h / 25 °C
2: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
3: 79 percent / NaOH / methanol / 2 h / Ambient temperature
4: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
5: NaOH / methanol / 24 h / 5 °C
6: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 6 steps
1: PCl5 / CH2Cl2 / 2 h / 25 °C
2: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
3: 79 percent / NaOH / methanol / 2 h / Ambient temperature
4: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
5: NaOH / methanol / 24 h / 5 °C
6: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 6 steps
1: PCl5 / CH2Cl2 / 2 h / 25 °C
2: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
3: 79 percent / NaOH / methanol / 2 h / Ambient temperature
4: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
5: NaOH / methanol / 24 h / 5 °C
6: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 6 steps
1: PCl5 / CH2Cl2 / 2 h / 25 °C
2: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
3: 79 percent / NaOH / methanol / 2 h / Ambient temperature
4: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
5: NaOH / methanol / 24 h / 5 °C
6: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
10-acetoxydecanoyl chloride
104967-12-6

10-acetoxydecanoyl chloride

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
2: 79 percent / NaOH / methanol / 2 h / Ambient temperature
3: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
4: NaOH / methanol / 24 h / 5 °C
5: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 5 steps
1: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
2: 79 percent / NaOH / methanol / 2 h / Ambient temperature
3: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
4: NaOH / methanol / 24 h / 5 °C
5: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 5 steps
1: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
2: 79 percent / NaOH / methanol / 2 h / Ambient temperature
3: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
4: NaOH / methanol / 24 h / 5 °C
5: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 5 steps
1: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
2: 79 percent / NaOH / methanol / 2 h / Ambient temperature
3: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
4: NaOH / methanol / 24 h / 5 °C
5: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / dichloromethane / 72 h / 4 °C
1.2: 8 h / 25 °C
2.1: dipotassium hydrogenphosphate; potassium hydroxylamine-N,N-disulphonate / N,N-dimethyl-formamide / 8 h / 50 °C
2.2: 8 h / 50 °C
2.3: 3 h / 80 °C
View Scheme
9-acetoxydecanenitrile
104967-00-2

9-acetoxydecanenitrile

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 44 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: AlCl3 / 1,2-dichloro-ethane / 5 degC, 2 h; 20 degC, 70 h
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Multi-step reaction with 7 steps
1: 86 percent / NaOH, 3N HCl / ethanol / 19 h / Heating
2: PCl5 / CH2Cl2 / 2 h / 25 °C
3: 29 percent / AlCl3 / 1,2-dichloro-ethane / 72 h / 20 °C
4: 79 percent / NaOH / methanol / 2 h / Ambient temperature
5: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
6: NaOH / methanol / 24 h / 5 °C
7: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
6-(10-hydroxy-1-oxodecyl)-2,3-dimethoxy-5-methylphenol
104966-97-4

6-(10-hydroxy-1-oxodecyl)-2,3-dimethoxy-5-methylphenol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
2: NaOH / methanol / 24 h / 5 °C
3: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
6-(10-acetoxydecyl)-2,3-dimethoxy-5-methylphenol
77712-30-2

6-(10-acetoxydecyl)-2,3-dimethoxy-5-methylphenol

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / methanol / 24 h / 5 °C
2: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
Acetic acid 10-(2-hydroxy-3,4-dimethoxy-6-methyl-phenyl)-10-oxo-decyl ester
104966-92-9

Acetic acid 10-(2-hydroxy-3,4-dimethoxy-6-methyl-phenyl)-10-oxo-decyl ester

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 79 percent / NaOH / methanol / 2 h / Ambient temperature
2: H2, 70percent HClO4 / 5percent Pd-C / 24 h / Ambient temperature
3: NaOH / methanol / 24 h / 5 °C
4: O2 / salcomine / dimethylformamide / Ambient temperature; reaction time, additive
View Scheme
9-ethoxycarbonylnonanoic acid chloride
6946-46-9

9-ethoxycarbonylnonanoic acid chloride

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: (i) AlCl3, (ii) (hydrolysis)
2: hydrogenchloride
3: potassium dihydrogenphosphate; potassium nitrososulfonate
4: (i) LiAlH4, (ii) aq. FeCl3
View Scheme
3,4,5-trimethoxytoluene
6443-69-2

3,4,5-trimethoxytoluene

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: nitric acid; potassium bromide / acetic anhydride / 1.25 h / 20 °C
2.1: palladium diacetate; triethylamine; triphenylphosphine / 72 h / 120 °C / Inert atmosphere
2.2: 3 h / 25 °C
3.1: iodine / 1 h / 25 °C
4.1: dihydrogen peroxide; toluene-4-sulfonic acid / acetic acid / 0.42 h / 75 °C
5.1: sodium carbonate / methanol; water / 20 h / 25 °C
View Scheme
Multi-step reaction with 4 steps
1: (i) AlCl3, (ii) (hydrolysis)
2: hydrogenchloride
3: potassium dihydrogenphosphate; potassium nitrososulfonate
4: (i) LiAlH4, (ii) aq. FeCl3
View Scheme
9-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)nonanoic acid
58185-79-8

9-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)nonanoic acid

Idebenone
58186-27-9

Idebenone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride
2: potassium dihydrogenphosphate; potassium nitrososulfonate
3: (i) LiAlH4, (ii) aq. FeCl3
View Scheme
nonanoic acid
112-05-0

nonanoic acid

Idebenone
58186-27-9

Idebenone

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl nonanoate

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl nonanoate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran for 24h; Reflux;100%
Idebenone
58186-27-9

Idebenone

[bromo(difluoro)methyl](trimethyl)silane
115262-01-6

[bromo(difluoro)methyl](trimethyl)silane

2-(10-(difluoromethoxy)decyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

2-(10-(difluoromethoxy)decyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With potassium hydrogen difluoride In dichloromethane; water at 20℃; for 10h; Reagent/catalyst;98%
Idebenone
58186-27-9

Idebenone

1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

C35H60O6

C35H60O6

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran for 24h; Reflux;97.4%
Idebenone
58186-27-9

Idebenone

2-(10-iododecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

2-(10-iododecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere;96%
Octanoic acid
124-07-2

Octanoic acid

Idebenone
58186-27-9

Idebenone

Idebenone octanoate
1177393-72-4

Idebenone octanoate

Conditions
ConditionsYield
With novozym 435 In toluene at 20℃; for 48h; 4A molecular sieves;92%
In ethyl acetate; toluene630 mg (92%)
silica gel In ethyl acetate; toluene630 mg (92%)
Idebenone
58186-27-9

Idebenone

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decyl methanesulfonate
845959-53-7

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decyl methanesulfonate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16h;91%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16h;91%
With triethylamine In dichloromethane at 10 - 15℃; for 1.5 - 1.75h;
Idebenone
58186-27-9

Idebenone

acetic anhydride
108-24-7

acetic anhydride

2,3-dimethoxy-5-methyl-6-(10'-acetoxydecyl)-1,4-benzoquinone
58186-28-0

2,3-dimethoxy-5-methyl-6-(10'-acetoxydecyl)-1,4-benzoquinone

Conditions
ConditionsYield
With pyridine In dichloromethane for 15h; Ambient temperature;90.7%
In pyridine
With pyridine
1-decanoic acid
334-48-5

1-decanoic acid

Idebenone
58186-27-9

Idebenone

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl decanoate

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl decanoate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran for 24h; Reflux;90.2%
valproic acid
99-66-1

valproic acid

Idebenone
58186-27-9

Idebenone

C27H44O6

C27H44O6

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran for 24h; Reflux;90.2%
linoleic acid
60-33-3

linoleic acid

Idebenone
58186-27-9

Idebenone

Idebenone Linoleate
1177393-70-2

Idebenone Linoleate

Conditions
ConditionsYield
With novozym 435 In toluene at 20℃; for 48h; 4A molecular sieves;87%
Idebenone
58186-27-9

Idebenone

Ag(1+)*CF3S(1-)*(x)C2H3N

Ag(1+)*CF3S(1-)*(x)C2H3N

2,3-dimethoxy-5-methyl-6-(10-((trifluoromethyl)thio)decyl)cyclohexa-2,5-diene-1,4-dione

2,3-dimethoxy-5-methyl-6-(10-((trifluoromethyl)thio)decyl)cyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With 1,2-Diiodoethane; tetra-(n-butyl)ammonium iodide; Diphenylvinylphosphine In N,N-dimethyl-formamide; acetonitrile at 80℃; for 0.25h; Inert atmosphere; Sealed tube;86%
Idebenone
58186-27-9

Idebenone

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decanal
89048-27-1

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decanal

Conditions
ConditionsYield
Stage #1: Idebenone With oxalyl dichloride; dimethyl sulfoxide In dichloromethane for 0.166667h;
Stage #2: With triethylamine In dichloromethane for 1h;
84%
With oxalyl dichloride; triethylamine In dichloromethane; dimethyl sulfoxide at -78℃; for 1.5h;84%
With sodium acetate; pyridinium chlorochromate In dichloromethane for 2.5h; Ambient temperature;38.7%
With Dess-Martin periodane In dichloromethane at 0℃; for 4h; Inert atmosphere;
Idebenone
58186-27-9

Idebenone

10-(2,3-Dimethoxy-5-methyl-1,4-benzoquinon-6-yl)decanoic acid
58185-99-2

10-(2,3-Dimethoxy-5-methyl-1,4-benzoquinon-6-yl)decanoic acid

Conditions
ConditionsYield
With Jones reagent In acetone83%
With phosphate buffer; D-glucose; rat liver slices at 37℃; for 1h; incubation, pH=7.4;
With Jones reagent In acetone at 0℃; for 0.333333h;
oxalyl dichloride
79-37-8

oxalyl dichloride

Idebenone
58186-27-9

Idebenone

C40H58O12

C40H58O12

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 3h; Inert atmosphere; Cooling with ice;83%
Idebenone
58186-27-9

Idebenone

3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid 10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl ester

3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid 10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In acetonitrile at 0 - 20℃; for 1.5h; Inert atmosphere;82%
Idebenone
58186-27-9

Idebenone

2-(10-fluorodecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

2-(10-fluorodecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; N-tosyl-4-chlorobenzenesulfonimidoyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 20℃; for 0.5h; Sealed tube;82%
lauric acid
143-07-7

lauric acid

Idebenone
58186-27-9

Idebenone

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl dodecanoate

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl dodecanoate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran for 24h; Reflux;81.1%
Idebenone
58186-27-9

Idebenone

trimethyl(pentafluoroethyl)silane
124898-13-1

trimethyl(pentafluoroethyl)silane

2,3-dimethoxy-5-methyl-6-(10-(perfluoroethoxy)decyl)cyclohexa-2,5-diene-1,4-dione

2,3-dimethoxy-5-methyl-6-(10-(perfluoroethoxy)decyl)cyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With potassium fluoride; 2-fluoropyridine; silver trifluoromethanesulfonate; lithium trifluoromethanesulfonate; Selectfluor In ethyl acetate at 20℃; for 12h; Inert atmosphere;80%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Idebenone
58186-27-9

Idebenone

di-tert-butyl 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-phenylene dicarbonate
1431987-50-6

di-tert-butyl 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-phenylene dicarbonate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃;79%
Idebenone
58186-27-9

Idebenone

C19H16ClNO4

C19H16ClNO4

C38H44ClNO8

C38H44ClNO8

Conditions
ConditionsYield
With sulfuric acid In cyclohexane at 25 - 65℃; Reflux;78%
Idebenone
58186-27-9

Idebenone

difluoromethyl-(4-nitrophenyl) bis(carbomethoxy) methylide sulfonium ylide

difluoromethyl-(4-nitrophenyl) bis(carbomethoxy) methylide sulfonium ylide

2-(10-(difluoromethoxy)decyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

2-(10-(difluoromethoxy)decyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With lithium tetrafluoroborate In dichloromethane at 30℃; for 1h;77%
Idebenone
58186-27-9

Idebenone

tetramethylammonium trifluoromethylselenate(0)
75264-92-5

tetramethylammonium trifluoromethylselenate(0)

2,3-dimethoxy-5-methyl-6-(10-((trifluoromethyl)selanyl)decyl)cyclohexa-2,5-diene-1,4-dione

2,3-dimethoxy-5-methyl-6-(10-((trifluoromethyl)selanyl)decyl)cyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With calcium chloride In acetonitrile at 60℃; Temperature; Inert atmosphere; Sealed tube; Glovebox;77%
Idebenone
58186-27-9

Idebenone

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decyl nitrate
1431986-91-2

10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)decyl nitrate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; tetrabutylammonium nitrate In dichloromethane at -70℃; for 2h;75%
With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; tetrabutylammonium nitrate In dichloromethane at -70℃; for 2h;75%
Multi-step reaction with 2 steps
1: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C
2: tetrabutylammonium nitrate; sodium nitrate / acetic acid butyl ester; acetonitrile / 18 h / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: dmap; triethylamine / dichloromethane / 16 h / 0 - 20 °C
2: sodium nitrate; tetrabutylammonium nitrate / acetic acid butyl ester; acetonitrile / 18 h / 80 °C
View Scheme
Idebenone
58186-27-9

Idebenone

(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

2,3-dimethoxy-5-methyl-6-(10-(trifluoromethoxy)decyl)cyclohexa-2,5-diene-1,4-dione

2,3-dimethoxy-5-methyl-6-(10-(trifluoromethoxy)decyl)cyclohexa-2,5-diene-1,4-dione

Conditions
ConditionsYield
With potassium fluoride; 2-fluoropyridine; silver trifluoromethanesulfonate; Selectfluor In ethyl acetate at 20℃; for 12h; Glovebox; Inert atmosphere;64%
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