58216-76-5Relevant academic research and scientific papers
Hydrogenation on granular palladium-containing catalysts: II. Hydrogenation of nitroheterocyclic compounds
Kislyi,Tolkacheva,Semenov
, p. 269 - 271 (2002)
Nitroheterocyclic compounds were reduced in a classical reactor with an agitator equipped with a cell for fixed bed of catalyst. As catalysts were applied granular palladium catalysts (0.5% of Pd on γ-Al2O 3 and 2% of Pd on granulated carbon). Anilines and 3-amino-2(1H)-pyridones were obtained in high yield at reduction of the appropriate nitro compounds, and the activity of the catalyst samples only slightly decreased. Yet aminopyrazoles and aminoimidazoles obtained by hydrogenation on palladium were very sensitive to the presence of air even as hydrochlorides. In the course of hydrogenation of nitropyrazoles and nitroimidazoles the activity of the catalyst markedly decreased.
Preparation, Structure and Addition Reactions of 4- and 5-Aminoimidazoles
Al-Shaar, Adnan H. M.,Gilmour, David W.,Lythgoe, David J.,McClenaghan, Ian,Ramsden, Christopher A.
, p. 2779 - 2788 (2007/10/02)
Catalytic reduction of 5-nitroimidazoles 4 in dioxane solution gives 5-aminoimidazoles 2 in good yield.The derivatives 2d-f were isolated as stable, crystalline compounds which undergo slow decomposition on exposure to air.In a similar manner, solutions o
