58219-80-0

Upstream product

• 2261-95-2 2-trifluoromethyl-4-benzyl-Δ³-oxazolin-5-one 
• 57103-30-7 4-(bromo-phenyl-methyl)-2-trifluoromethyl-2H-oxazol-5-one 
• 101047-18-1 C₁₈H₂₈F₃NO₄Si₂ 
• 186581-53-3 diazomethane 
• 58219-79-7 Z-α-Trifluoracetamidozimtsaeure 
• 150-30-1 Phenylalanine 
• 129871-71-2 3-(Methylsulfonyloxy)-3-phenyl-2-<(trifluoracetyl)amino>propansaeure-methylester 
• 129871-73-4 3-(Methylsulfonyloxy)-3-phenyl-2-<(trifluoracetyl)(trimethylsilyl)amino>propansaeure-methylester 

Downstream Products

• 129871-74-5 (Z)-3-Phenyl-2-<(trifluoracetyl)(trimethylsilyl)amino>propensaeure-methylester 

Relevant academic research and scientific papers

Reactions of Trialkylsilyl Trifluoromethanesulfonates, X. - N-(Trifluoroacetyl)-α,β-didehydro-α-amino Carboxylic Acid Esters from 2--3-(trimethylsiloxy)carboxylic Acid Esters by Elimination of Trimethylsilanol

α-Amino-β-(trimethylsiloxy)carboxylates 4 are obtained by trimethylsiloxy alkylation of the ketene acetal 1 with aldehydes 2 in the presence of trimethylsilyl triflate (3). β-Elimination of trimethylsilanol from the esters 4 by means of trifluoroacetic acid anhydride (8) or methanesulfonic acid anhydride (15) yields (Z)-didehydro amino acid esters 7.The course of the elimination reaction is studied.

Synthese von N-Trifluoroacetyl-dehydroaminosaeureestern

The synthesis of (Z)-N-trifluoroacetyl-dehydroamino acids via trimethylsilanol elimination from 2-(N-trifluoroacetyl-N-trimethylsilylamino)-3-trimethylsiloxyalkanoic acid esters by methanesulfonic or trifluoroacetic acid anhydride is described.