58226-80-5

Basic information

• Product Name: 6-bromo-2-(4-chlorophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
• Synonyms: 6-bromo-2-(4-chlorophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
• CAS NO: 58226-80-5
• Molecular Formula: C18H9BrClNO2
• Molecular Weight: 386.62656
• Mol File: 58226-80-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-bromo-2-(4-chlorophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-2-(4-chlorophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione(58226-80-5)
• EPA Substance Registry System: 6-bromo-2-(4-chlorophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione(58226-80-5)

Safety Data

• Hazardous Substances Data: 58226-80-5(Hazardous Substances Data)

Upstream product

• 81-86-7 4-bromo-1,8-naphthalenedicarboxylic anhydride 
• 106-47-8 4-chloro-aniline 

Relevant articles and documents

A lysosome-targetable fluorescent probe for imaging trivalent cations Fe3+, Al3+ and Cr3+ in living cells

An effective morpholine-type naphthalimide chemsensor, N-p-chlorophenyl-4-(2-aminoethyl)morpholine-1,8-naphthalimide (CMN) has been developed as a lysosome-targeted fluorometric sensor for trivalent metal ions (Fe3+, Al3+ and Cr3+). Upon the addition of Fe3+, Al3+ or Cr3+ ions, the probe CMN showed an evident naked-eye color changes which pale yellow solution of CMN turned deepened and it displayed turn-on fluorescence response in methanol. CMN showed a significant selective and sensitive toward Fe3+, Al3+ or Cr3+ ions, while there was no obvious behavior to other monovalent or divalent metal ions from the UV–vis and fluorescence spectrum. Based on the Job's plot analyses the 1:1 coordination mode of CMN with Fe3+, Al3+ or Cr3+ was proposed. The limit of detection (LOD) observed were 0.65, 0.69 and 0.68 μM for Fe3+, Al3+ and Cr3+ ions, respectively. The N-atom of morpholine directly involved in complex formation, CMN emitted fluorescence through inhibition of photoinduced electron transfer (PET). This probe exhibited excellent imaging ability for Fe3+, Al3+and Cr3+ ions in living cells with low cytotoxicity. Significantly, the cellular confocal microscopic research indicated that the lysosome-targeted group of morpholine moiety was introduced which realized the capability of imaging lysosomal trivalent metal ions in living cells for the first time.