58236-91-2

Usage

InChI:InChI=1/C10H9ClO2/c1-2-5-13-10-4-3-8(7-12)6-9(10)11/h2-4,6-7H,1,5H2

Upstream product

• 22131-79-9 aclofenac 
• 106-95-6 allyl bromide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 2420-16-8 4-hydroxy-3-chlorobenzaldehyde 

Downstream Products

• 854107-60-1 4-(2,3-dihydroxypropoxy)-3-chlorobenzaldehyde 
• 144478-99-9 (4-allyloxy-3-chlorophenyl)methanol 
• 851968-85-9 (2S,3R)-2-Allyloxycarbonylamino-3-(4-allyloxy-3-chloro-phenyl)-3-hydroxy-propionic acid 
• 851968-84-8 (4S,5R)-5-(4-Allyloxy-3-chloro-phenyl)-2-thioxo-oxazolidine-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOUNDS FOR USE IN METHODS FOR TREATING DISEASES OR CONDITIONS MEDIATED BY PROTEIN DISULFIDE ISOMERASE

The invention provides compounds of formula (I) that inhibit PDI, for use in methods to treat or prevent a disease or condition in a subject that would benefit by inhibition of PDI. Formula (I)

CARBOXAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS

The invention relates to compounds of Formula (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.

5-(BENZ- (Z) -YLIDENE) -THIAZOLIDIN-4-ONE DERIVATIVES AS IMMUNOSUPPRESSANT AGENTS

The invention relates to pharmaceutical compositions containing at least one 5- (benz- (Z) -ylidene-thiazolidin-4-one derivative (I), to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thi

An improved solid-phase methodology for the synthesis of putative hexa- and heptapeptide intermediates in vancomycin biosynthesis

The biosynthesis of the vancomycin aglycone involves three oxidative phenol coupling reactions, each catalyzed by a discrete cytochrome P450-like enzyme. Studies on the mechanism and specificity of the enzyme (called OxyB) catalyzing the first coupling, require access to suitable linear peptide precursors, each conjugated as a thioester to a peptide carrier domain of the vancomycin non-ribosomal peptide synthetase. An efficient route to representative free linear peptides is described here. The method makes use of Alloc-chemistry during solid-phase assembly of the peptide backbone, but importantly and in contrast to earlier efforts, largely avoids the use of amino acid side chain protecting groups. In this way, the target linear peptides can be released directly from the solid support under very mild conditions. The Royal Society of Chemistry 2005.

OXIDATIVE DECARBOXYLATION OF CARBOXYLIC ACIDS BY IRON PORPHYRIN - IODOSYLBENZENE SYSTEM

An iodosylbenzene - iron tetraarylporphyrin catalyst system decarboxylated α-aryl carboxylic acids and α,α,α-trisubstituted acetic acids efficiently to give the corresponding alcohol and carbonyl derivatives.