58243-74-6Relevant academic research and scientific papers
Highly regioselective transformation of alkenyl bromides into α-bromoaziridines and α-bromohydrazones
Krasnova, Larissa B.,Yudin, Andrei K.
, p. 2011 - 2014 (2006)
The synthetic utility of α-halohydrazones is an underexplored area due to the lack of chemo- and regioselective routes towards these molecules. Herein, we describe a general method for α-bromohydrazone synthesis via the rearrangement of α-bromoaziridines,
Sodium-iodoxybenzoate mediated highly chemoselective aziridination of olefins
Bakthavachalam, Ananthan,Chuang, Hui-Chun,Yan, Tu-Hsin
, p. 5884 - 5894 (2015/03/30)
Herein we utilized, for the first time, sodium 2-iodoxybenzoate as a highly specific oxidant for PhthNH2 to create a highly chemoselective aziridination reagent. This method efficiently effects aziridination of electron-rich, electron-deficient, allylic alcohol and alkenyl bromide C=C bonds in good to excellent yields. Inter and intramolecular chemoselectivity was demonstrated between electron-rich and electron-deficient alkenes by using this efficient and metal free protocol.
