58259-44-2Relevant academic research and scientific papers
1,4-Dihydropyridines
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, (2008/06/13)
Derivatives of 4-substituted phenyl 1,4-dihydropyridine 3,5-dicarboxylic acids substituted by lower alkyl groups in the 2- and 6-positions, are cardiovascular agents. The compounds, of which 2,6-dimethyl-4-[2-(diethylaminoethoxy)-phenyl]-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a typical example, can be prepared through condensation of a β-dicarbonyl compound with an amine and an aldehyde, of an ylidene-β-ketocarboxylic acid ester, with a β-ketocarbonyl compound and an amine, of an aldehyde, an enamine and a β-ketocarbonyl compound, or through elaboration of the substituent on the phenyl group.
