58261-91-9

Basic information

• Product Name: (5-METHYL-2-PHENYL-1H-IMIDAZOL-4-YL)-ACETONITRILE
• Synonyms: (5-METHYL-2-PHENYL-1H-IMIDAZOL-4-YL)-ACETONITRILE;Mefenidil;5-Methyl-2-phenyl-1H-imidazole-4-acetonitrile;McN-2378
• CAS NO: 58261-91-9
• Molecular Formula: C₁₂H₁₁N₃
• Molecular Weight: 197.23584
• Mol File: 58261-91-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 457.8 °C at 760 mmHg
• Flash Point: 146.5 °C
• Appearance: /
• Density: 1.168 g/cm³
• Vapor Pressure: 1.44E-08mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: (5-METHYL-2-PHENYL-1H-IMIDAZOL-4-YL)-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-METHYL-2-PHENYL-1H-IMIDAZOL-4-YL)-ACETONITRILE(58261-91-9)
• EPA Substance Registry System: (5-METHYL-2-PHENYL-1H-IMIDAZOL-4-YL)-ACETONITRILE(58261-91-9)

Safety Data

• Hazardous Substances Data: 58261-91-9(Hazardous Substances Data)

Usage

Uses

Vasodilator (cerebral).

InChI:InChI=1/C12H11N3/c1-9-11(7-8-13)15-12(14-9)10-5-3-2-4-6-10/h2-6H,7H2,1H3,(H,14,15)

Upstream product

• 58731-95-6 4-chloromethyl-5-methyl-2-phenyl-1H-imidazole hydrochloride 

Relevant articles and documents

Bicyclic heteroamatic compounds useful as LH agonists

The invention relates to a bicyclic heteroaromatic derivative compound according to general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1is NR5R6, OR5, SR5or R7; R5and R6are independently selected from H, (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, alkyl(1-8C)carbonyl, (6-14C)arylcarbonyl, (6-14C)aryl or (4-13C)heteroaryl, or R5and R6together are joined in a (2-7C)heterocloalkyl ring; R7is (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl or (4-13C)heteroaryl, R2is (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, or (6-14C)aryl or (4-13C)heteroaryl, both optionally substituted with one or more substituents selected from (1-8C)alkyl, (1-8C)alkylthio, (1-8C)(di)alkylamino, (1-8C)alkoxy, (2-8C)alkenyl, or (2-8C)alkynyl; R3is (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, or (6-14C)aryl or (4-13C)heteroaryl, both optionally substituted with one or more substituents selected from (1-8C)alkyl, (1-8C)(di)alkylamino or (1-8C)alkoxy; X is S, O or N(R4); R4is H, (1-8C)alkyl, (1-8C)alkylcarbonyl, (6-14C)arylcarbonyl or (6-14C)aryl(1-8C)alkyl; Y is CH or N; Z is NH2or OH; A is S, N(H), N(R9), O or a bond; R9can be selected from the same groups as described for R2and B is N(H), O or a bond. The compounds of the invention have LH receptor activating activity and can be used in fertility regulating therapies.