58288-73-6Relevant academic research and scientific papers
Heterocyclic S-imino-S-oxides
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, (2008/06/13)
The invention relates to new heterocyclic S-imino-S-oxides of the formula I STR1 in which one of the symbols X1 and X2 denotes a direct bond and the other denotes the vinylene group --CH=CH-- or the epithio radical --S--, Y1 and Y2 conjointly denote an additional bond or one of the symbols denotes hydrogen and the other denotes hydrogen or, conjointly with the symbol R1 or R2, which is present on the same carbon atom, denotes the oxo radical, one of the symbols R1 and R2 denotes hydrogen or lower alkyl and the other denotes hydrogen or lower alkyl or, conjointly with the symbol Y1 or Y2, which is present on the same carbon atom, denotes the oxo radical, or, if Y1 and Y2 conjointly denote an additional bond, also denotes lower alkoxy, and R3 and R4 independently of one another denote hydrogen, halogen up to atomic number 35, lower alkyl, lower alkoxy or trifluoromethyl and R5 denotes hydrogen or lower alkyl, and to their acid addition salts in particular the pharmaceutically with inorganic and organic acceptable acid addition salts. These new compounds possess valuable pharmacological properties. In particular they have an anticonvulsive activity and are useful for the treatment of epilepsy and of states of tension and states of agitation.
