58292-66-3

Upstream product

• 353-85-5 trifluoroacetonitrile 
• 106-38-7 para-bromotoluene 
• 394-59-2 2,2,2-trifluoro-1-(p-tolyl)ethanone 
• 58593-90-1 1-(4-tolyl)-2,2,2-trifluoro-1-chloroethylisocyanate 
• 141264-45-1 2-(2,2,2-Trifluoro-1-isocyanato-1-p-tolyl-ethylsulfanyl)-benzooxazole 

Downstream Products

• 1078145-49-9 ethyl 2,2,2-trifluoro-1-(4-methylphenyl)ethylidenecarbamate 
• 1030852-43-7 C₁₂H₁₆F₃NO 
• 1030852-46-0 C₁₂H₁₅F₃N₂O 
• 1030852-38-0 (-)-(4S)-4-amino-4-(4-methylphenyl)-5,5,5-trifluoropentan-2-one 
• 1212397-86-8 C₁₂H₁₄F₃NO 
• 134329-11-6 Dimethyl (1-amino-1-tolyl-2,2,2-trifluoroethyl)phosphonate 
• 58292-63-0 C₁₈H₁₄F₆N₂S 

Relevant academic research and scientific papers

Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to N-Unprotected Ketimines: Efficient Synthesis of Cipargamin

Highly enantioselective rhodium-catalyzed addition of arylboroxines to N-unprotected ketimines is realized for the first time by employing chiral BIBOP-type ligands with a Rh loading as low as 1 mol %. A range of chiral α-trifluoromethyl-α,α-diaryl α-tertiary amines or 3-amino-3-aryloxindoles were formed with excellent ee values and yields by employing either WingPhos or PFBO-BIBOP as the ligand. The method has enabled an efficient enantioselective synthesis of cipargamin.

Tertiary amine compound, bisphosphine ligand, and intermediate and preparation method of tertiary amine compound

The invention discloses a tertiary amine compound, a bisphosphine ligand, and an intermediate and a preparation method of the tertiary amine compound, and provides a tertiary amine compound preparation method, which comprises: under the protection of a ga

Enantioselective Friedel–Crafts Alkylation Reaction of Heteroarenes with N-Unprotected Trifluoromethyl Ketimines by Means of Chiral Phosphoric Acid

An enantioselective Friedel–Crafts alkylation reaction of pyrroles and indoles with N-unprotected trifluoromethyl ketimines by use of chiral phosphoric acid provided α-trifluoromethylated primary amines bearing chiral tetrasubstituted carbon centers in high yields and with high to excellent enantioselectivities. The present reaction is unique to N-unprotected trifluoromethyl ketimines. No reaction took place with N-p-methoxyphenyl (PMP)-substituted ketimine. Corresponding α-trifluoromethylated amines were transformed without loss of enantioselectivity.

Direct access to: N -unprotected tetrasubstituted propargylamines via direct catalytic alkynylation of N -unprotected trifluoromethyl ketimines

Direct catalytic alkynylation of N-unprotected trifluoromethyl ketimines is reported for the first time. A combination of catalytic amounts of diethylzinc and carboxylic acids promoted the reactions under proton-transfer conditions, allowing an unprecedented direct access to N-unprotected α-tetrasubstituted primary amines without additional deprotection steps.

1-(2-HETERYLTHIO)ALKYL ISOCYANATES SYNTHESIS AND REACTIONS WITH PROTON-CONTAINING NUCLEOPHILIC REAGENTS

The alkylation of benzazoline-2-thiones and quinoline-2-thione by 1-chloroalkyl isocyanates gave 1-(2-heterylthio)alkyl isocyanates.Depending on their nature, the reactions of the products with water, alcohols, phenols, and amines led to the formation of