58294-83-0

Basic information

• Product Name: 2,4-diphenyl-but-3-yne-1,2-diol
• Synonyms: 2,4-diphenyl-but-3-yne-1,2-diol
• CAS NO: 58294-83-0
• Molecular Weight: 238.286
• Mol File: 58294-83-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2,4-diphenyl-but-3-yne-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-diphenyl-but-3-yne-1,2-diol(58294-83-0)
• EPA Substance Registry System: 2,4-diphenyl-but-3-yne-1,2-diol(58294-83-0)

Safety Data

• Hazardous Substances Data: 58294-83-0(Hazardous Substances Data)

Upstream product

• 582-24-1 1-phenyl-2-hydroxyethanone 
• 536-74-3 phenylacetylene 
• 6738-06-3 phenylethynylmagnesium bromide 
• 4440-01-1 lithium phenylacetylide 

Downstream Products

• 5369-55-1 2,4-diphenylfuran 
• 1221575-74-1 methyl 2,4-diphenylfuran-3-carboxylate 
• 1395472-72-6 C₁₆H₁₁IO 

Relevant articles and documents

Rh(I)-Catalyzed Decarboxylative Arylation of Alkynyl Cyclic Carbonates: Divergent Access to Substituted α-Allenols and 1,3-Butadienes

Rh(I)-catalyzed decarboxylative arylation of alkynyl cyclic carbonates using commercially available and low-toxic aryl boronic acids has been disclosed. Depending on the nature of the cyclic carbonates, the methodology provides a straightforward platform to access either substituted 2,3-allenols or 1,3-butadiene derivatives. Internal alkynyl cyclic carbonates undergo monoarylation to conveniently afford 2,3-allenols with high syn-selectivity for the aryl and hydroxy groups. Whereas, terminal alkynyl carbonates led to the formation of diarylated 1,3-butadiene derivatives having cis-configuration for the two aryl groups via allenyl rhodium(I)alkoxide intermediate. The compatibility of various functional groups allowed to develop a library of diversely functionalized scaffolds with excellent regioselectivity in good yields. Late-stage transformation of a series of natural products highlights the wide applicability of the arylation process. Additionally, scale-up experiments and downstream transformations of α-allenol derivatives into other valuable heterocycles illustrate the efficacy of the protocol.

Poly(ethylene glycol) as a reaction matrix in platinum- or gold-catalyzed cycloisomerization: A mechanistic investigation

Design for diversity: A new catalytic system based on PEG-3400 and a metal salt (Pt or Au) was designed to efficiently perform a cycloisomerization reaction under microwave irradiation, which gave diverse heterocycles in good to excellent yields, after a

A simple and convenient synthesis of substituted furans and pyrroles by CuCl2-catalyzed heterocyclodehydration of 3-yne-1,2-diols and N-Boc- or N-tosyl-1-amino-3-yn-2-ols

A simple and economical synthesis of substituted furans and pyrroles, by ligand-free CuCl2-catalyzed heterocyclodehydration of readily available 3-yne-1,2-diols and N-Boc- or N-tosyl-1-amino-3-yn-2-ols, respectively, is presented. Reactions are carried out in MeOH at 80-100 °C for 1-24 h and afford the corresponding heterocyclic derivatives in 53-99% isolated yields.