58304-99-7Relevant academic research and scientific papers
Some new acyclic nucleotide analogues as antiviral prodrugs: Synthesis and bioactivities in vitro
Tang, Yan-bo,Peng, Zong-gen,Liu, Zong-ying,Li, Yan-ping,Jiang, Jian-dong,Li, Zhuo-rong
, p. 6350 - 6353 (2008/09/17)
A series of ester analogues of acyclic nucleotide PMPA and PMEA were synthesized as potent antiviral agents. The antiviral evaluation results indicated that bis benzyl ester prodrug of PMPA 5f and bis allyl ester prodrug of PMEA 5g exhibited potent antiviral activities. The IC50 of 5f for HBV was 2.15 μM, and the IC50 of 5g for HIV-1 was 1.61 μM.
Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons
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, (2008/06/13)
Contrast agents comprising gas-containing or gas-generating polymer microparticles and/or microballoons, in which the polymer is a biodegradable polymer containing units of formula (wherein R1 and R2 each represent hydrogen or a carbon-attached monovalent organic group or together form a carbon-attached divalent organic group, and m and n are each independently zero or one) may be used in diagnostic applications such as ultrasound and MR imaging.
