5832-00-8

Basic information

• Product Name: 5-Nitrothiophene-2-carboxamide
• Synonyms: 5-Nitrothiophene-2-carboxamide
• CAS NO: 5832-00-8
• Molecular Formula: C5H4N2O3S
• Molecular Weight: 172.16
• Mol File: 5832-00-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 334.2°Cat760mmHg
• Flash Point: 155.9°C
• Appearance: /
• Density: 1.572g/cm³
• Vapor Pressure: 0.00013mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 5-Nitrothiophene-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Nitrothiophene-2-carboxamide(5832-00-8)
• EPA Substance Registry System: 5-Nitrothiophene-2-carboxamide(5832-00-8)

Safety Data

• Hazardous Substances Data: 5832-00-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H4N2O3S/c6-5(8)3-1-2-4(11-3)7(9)10/h1-2H,(H2,6,8)

Upstream product

• 6317-37-9 5-nitrothiophene-2-carboxylic acid 
• 39978-57-9 5-nitrothiophene-2-carbonyl chloride 
• 16689-02-4 5-nitro-2-thienyl cyanide 
• 1003-31-2 thiophene-2-carbonitrile 

Downstream Products

• 224449-29-0 5-(phenyloxycarbonylamino)thiophene-2-carboxamide 
• 763068-76-4 5-aminothiophene-2-carboxylic acid amide 

Relevant articles and documents

SUBSTITUTED OXOPYRIDINE DERIVATIVES

The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Labelled compounds of interest as antitumour agents - VI. Isotopically efficient syntheses of [15N]-nitrothiophenecarboxamides

Reaction of 3-cyanothiophene with one equivalent of potassium nitrate in concentrated sulphuric acid causes nitration, concurrent with hydrolysis of the nitrile, to give 5-nitro-thiophene-3-carboxamide in high yield. Similarly, 2-cyanothiophene gives 4-nitro-thiophene-2-carboxamide and 5-nitrothiophene-2-carboxamide, benzonitrile gives 3-nitrobenzamide and 4-methylbenzonitrile gives 4-methyl-3-nitrobenzamide. Extension of this process to use of potassium [15N]-nitrate, formed from [15N]-nitric acid (95% isotopic enrichment), enables preparation of the corresponding [15N]-nitrothiophenecarboxamides in high isotopic yield.