5832-00-8Relevant academic research and scientific papers
SUBSTITUTED OXOPYRIDINE DERIVATIVES
-
Paragraph 0486; 0487; 0500-0503, (2018/05/24)
The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
INHIBITORS OF JANUS KINASES
-
Page/Page column 102, (2009/01/23)
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
Labelled compounds of interest as antitumour agents - VI. Isotopically efficient syntheses of [15N]-nitrothiophenecarboxamides
Shinkwin, Anne E.,Threadgill, Michael D.
, p. 1015 - 1020 (2007/10/03)
Reaction of 3-cyanothiophene with one equivalent of potassium nitrate in concentrated sulphuric acid causes nitration, concurrent with hydrolysis of the nitrile, to give 5-nitro-thiophene-3-carboxamide in high yield. Similarly, 2-cyanothiophene gives 4-nitro-thiophene-2-carboxamide and 5-nitrothiophene-2-carboxamide, benzonitrile gives 3-nitrobenzamide and 4-methylbenzonitrile gives 4-methyl-3-nitrobenzamide. Extension of this process to use of potassium [15N]-nitrate, formed from [15N]-nitric acid (95% isotopic enrichment), enables preparation of the corresponding [15N]-nitrothiophenecarboxamides in high isotopic yield.
