58327-77-8

Upstream product

• 58327-70-1 2-carbethoxy-3-amino-4,6-diphenylthieno<2,3-b>pyridine 
• 94361-03-2 4,6-diphenyl-3-cyano-2-pyridylacetic acid 
• 58327-74-5 4,6-diphenyl-2-mercaptonicotinonitrile 
• 58327-74-5 4,6-diphenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 

Downstream Products

• 58327-80-3 4,6-diphenyl-thieno[2,3-b]pyridin-3-ol 
• 58327-88-1 2-methyl-7,9-diphenylpyrido<3',2':4,5>thieno<3,2-d><3,1>-4-oxazinone 
• 94639-90-4 3-amino-4,6-diphenylthieno<2,3-b>pyridine 
• 148975-95-5 7,9-Diphenyl-pyrido[3',2':4,5]thieno[3,2-d][1,3]oxazin-4-one 
• 94639-65-3 2-methyl-7,9-diphenyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one 
• 94639-97-1 (4,6-Diphenyl-thieno[2,3-b]pyridin-3-yl)-[1-(4-fluoro-phenyl)-meth-(Z)-ylidene]-amine 
• 94639-98-2 [1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-(4,6-diphenyl-thieno[2,3-b]pyridin-3-yl)-amine 
• 94639-99-3 [1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-(4,6-diphenyl-thieno[2,3-b]pyridin-3-yl)-amine 
• 94639-66-4 3-acetylamino-2-carbamoyl-4,6-diphenylthieno<2,3-b>pyridine 
• 94639-94-8 1-(4,6-Diphenyl-thieno[2,3-b]pyridin-3-yl)-3-phenyl-urea 
• 94639-69-7 3-amino-2-methyl-7,9-diphenylpyrido<3',2':4,5>thieno<3,2-d>-4(3H)-pyrimidinone 
• 94640-01-4 (4,6-Diphenyl-thieno[2,3-b]pyridin-3-yl)-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-amine 
• 94640-00-3 (4,6-Diphenyl-thieno[2,3-b]pyridin-3-yl)-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-amine 
• 94639-95-9 1-(3-Chloro-phenyl)-3-(4,6-diphenyl-thieno[2,3-b]pyridin-3-yl)-urea 

Relevant academic research and scientific papers

Bicyclic heteroamatic compounds useful as LH agonists

The invention relates to a bicyclic heteroaromatic derivative compound according to general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1is NR5R6, OR5, SR5or R7; R5and R6are independently selected from H, (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, alkyl(1-8C)carbonyl, (6-14C)arylcarbonyl, (6-14C)aryl or (4-13C)heteroaryl, or R5and R6together are joined in a (2-7C)heterocloalkyl ring; R7is (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl or (4-13C)heteroaryl, R2is (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, or (6-14C)aryl or (4-13C)heteroaryl, both optionally substituted with one or more substituents selected from (1-8C)alkyl, (1-8C)alkylthio, (1-8C)(di)alkylamino, (1-8C)alkoxy, (2-8C)alkenyl, or (2-8C)alkynyl; R3is (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, or (6-14C)aryl or (4-13C)heteroaryl, both optionally substituted with one or more substituents selected from (1-8C)alkyl, (1-8C)(di)alkylamino or (1-8C)alkoxy; X is S, O or N(R4); R4is H, (1-8C)alkyl, (1-8C)alkylcarbonyl, (6-14C)arylcarbonyl or (6-14C)aryl(1-8C)alkyl; Y is CH or N; Z is NH2or OH; A is S, N(H), N(R9), O or a bond; R9can be selected from the same groups as described for R2and B is N(H), O or a bond. The compounds of the invention have LH receptor activating activity and can be used in fertility regulating therapies.

CYCLIZATION OF NITRILES. IX. SYNTHESES BASED ON 2-ARYL-3-AROYL-1,1-DICYANOPROPANES

2-Aryl-3-aroyl-1,1-dicyanopropanes and 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes were synthesized from chalcones and malononitrile and were converted into 4,6-diaryl-2-bromo-3-cyanopyridines and 3-cyano-2(1H)-pyridinethiones.The 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes proved convenient intermediates for the production of the corresponding cyclopropanes and other compounds.By their reaction with urea a new method was developed for the production of substituted 3-cyano-2(1H)-pyridinethiones.The 2-bromo-3-cyanopyridines contain a mobile bromine atom readily exchanged for the various nucleophilic residues of alcohols and amines and for iodide, and cyano and thiocyanato groups.The 3-cyano-2(1H)-pyridinethiones were used in the synthesis of 3-aminothienopyridines through the isolated 2-Z-methylthio-3-cyanopyridines.

CYCLIZATION OF NITRILES. XI. SYNTHESIS AND REACTIONS OF 3-AMINO-2-CARBOXYTHIENOPYRIDINES

Derivatives of 3-cyano-2-pyridylthioacetic acid were synthesized by the reaction of substituted 3-cyano-2(1H)-pyridinethiones with monobromoacetic acid.They were converted by the Thorpe-Ziegler reaction into the corresponding 3-amino-2-carboxythieno2,3-b