58349-02-3

Basic information

• Product Name: 4-bromo-2-iodo-6-nitrophenol
• Synonyms: 4-bromo-2-iodo-6-nitrophenol
• CAS NO: 58349-02-3
• Molecular Weight: 343.903
• Mol File: 58349-02-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-bromo-2-iodo-6-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2-iodo-6-nitrophenol(58349-02-3)
• EPA Substance Registry System: 4-bromo-2-iodo-6-nitrophenol(58349-02-3)

Safety Data

• Hazardous Substances Data: 58349-02-3(Hazardous Substances Data)

Upstream product

• 7693-52-9 4-bromo-2-nitrophenol 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 376592-93-7 3′-amino-2′-hydroxy biphenyl-3-carboxylic acid 

Relevant articles and documents

Preparation method of eltrombopag intermediate and preparation method of eltrombopag diethanolamine salt

The invention provides a preparation method of an eltrombopag intermediate and a preparation method of eltrombopag diethanolamine salt, and relates to the technical field of medicinal chemistry. According to the preparation method of the eltrombopag intermediate, p-bromophenol is taken as a raw material, and the problem of poor selectivity of nitration reaction is solved. After iodination, the coupling reaction yield of the intermediate compound as shown in a formula (I) and phenylboronic acid is high. Subsequently reduction reaction is carried out, the debromination reaction is complete, the yield is 90% or more, the refining is simpler, and the synthesis yield of the compound of the formula (I) is higher and the operation is simple. Through the improvement, the yield of the key compound shown as the formula (I) is relatively high, the subsequent treatment operation is simple, the process is easy for amplified production, the yield of the whole synthesis process of the eltrombopag diethanolamine salt is 48.1%, the operation is simple, less three wastes are generated, and the synthesis process is suitable for amplified production.