58351-20-5

Basic information

• Product Name: 1-(2-(4-chlorophenoxy)phenyl)ethan-1-one
• Synonyms: 1-(2-(4-chlorophenoxy)phenyl)ethan-1-one
• CAS NO: 58351-20-5
• Molecular Weight: 246.693
• Mol File: 58351-20-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(2-(4-chlorophenoxy)phenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(4-chlorophenoxy)phenyl)ethan-1-one(58351-20-5)
• EPA Substance Registry System: 1-(2-(4-chlorophenoxy)phenyl)ethan-1-one(58351-20-5)

Safety Data

• Hazardous Substances Data: 58351-20-5(Hazardous Substances Data)

Upstream product

• 445-27-2 2'-Fluoroacetophenone 
• 106-48-9 4-chloro-phenol 
• 2142-68-9 1-(2-chlorophenyl)ethanone 

Downstream Products

• 25563-04-6 o-(p-chlorophenoxy)phenylacetic acid 
• 345308-89-6 2-[2-(4-Chloro-phenoxy)-phenyl]-1-morpholin-4-yl-ethanethione 

Relevant articles and documents

Affinity of 10-(4-Methylpiperazino)dibenzoxepins for Clozapine and Spiroperidol Binding Sites in Rat Brain

10-(4-Methylpiperazino)dibenzoxepins were prepared and evaluated as potential antipsychotic agents using specific clozapine diazepine> binding sites in rat forebrain that are noncholinergic and nondopaminergic in nature and from which clozapine is displaced by known antipsychotic agents. Clozapine binding in the presence of atropine represents nonmuscarinic binding, while binding in the absence of atropine represents muscarinic (cholinergic) plus nonmuscarinic binding.The relative affinity for dopamine binding sites was determined by displacement of spiroperidol from binding sites in rat caudate nuclei.Thus, clozapine, its 2-chloro isomer, its dechloro analogue, and their 5H-dibenzocycloheptene and dibenzoxepin analogues have about the same relative affinity for the nonmuscarinic clozapine binding sites.At the spiroperidol (dopaminergic) sites, both the nature of the tricyclic system and the presence of chlorine atom on the tricyclic system have a substantial effect on the binding affinity.Within each series, shift of a chlorine atom from the position distal to the piperazino group to the proximal position increases the binding affinity by a factor of about nine, but removal of the chlorine atom substantially decreases the binding affinity.Nevertheless, 10-(4-methylpiperazino)dibenzoxepin has a threefold greater affinity for the dopaminergic binding sites than does clozapine itself.

Transition-metal-free intramolecular carbene aromatic substitution/Büchner reaction: Synthesis of fluorenes and [6,5,7]benzo-fused rings

Intramolecular aromatic substitution and Büchner reaction have been established as powerful methods for the construction of polycyclic compounds. These reactions are traditionally catalyzed by RhII catalysts with a-diazocarbonyl compounds as the substrates. Herein a transition-metal-free intramolecular aromatic substitution/Büchner reaction is presented. These reactions use readily available N-tosylhydrazones as the diazo compound precursors and show wide substrate scope.

Dichloroacyl diphenyl ether mite ovacides

Compounds having the formula STR1 wherein one of X or Y is chloro and the other is trifluoromethyl or wherein X is hydrogen and Y is chloro and methods of preparing said compounds. The compounds can be prepared by the reaction of the corresponding 1-acety