58367-04-7Relevant academic research and scientific papers
(+)-Agelasine D: Improved synthesis and evaluation of antibacterial and cytotoxic activities
Vik, Anders,Hedner, Erik,Charnock, Colin,Samuelsen, rjan,Larsson, Rolf,Gundersen, Lise-Lotte,Bohlin, Lars
, p. 381 - 386 (2008/12/22)
An improved synthesis of (+)-agelasine D (10) from (+)-manool is reported together with cytotoxic and antibacterial data for agelasine D and structurally close synthetic analogues. These compounds display a broad spectrum of antibacterial activities including effects on M. tuberculosis and Gram-positive and Gram-negative bacteria (both aerobes and anaerobes). They exhibit profound cytotoxic activity against several cancer cells, including a multidrug-resistant cell line. (+)-Agelasine D (10) has been isolated earlier from a marine sponge (Agelas sp.).
Purines. XXV. Fission and Reclosure of the Adenine Ring by the Use of Modified Benzyloxy Groups at the 1-Position
Fujii, Tozo,Itaya, Taisuke,Saito, Tohru,Kawakatsu, Satoshi
, p. 4842 - 4851 (2007/10/02)
The rates of the three reactions in the system that produces the rearranged isomers 4a-d and the 5-aminoimidazole derivatives 6a-d from 1-benzyloxy- and 1-(modified benzyloxy)-9-methyladenine perchlorates (2a-d.HClO4) through the isolable ring-
