58372-39-7Relevant academic research and scientific papers
Synthesis and cytotoxicity of 2-methyl-1-substituted-imidazo[4,5-g]quinoline-4,9-dione and 7,8-dihydro-10H-[1,4]oxazino[3',4':2,3]imidazo[4,5-g]quinoline-5,12-dione derivatives
Suh, Myung-Eun,Kang, Min-Jung,Yoo, Hee-Won,Park, So-Young,Lee, Chong-Ock
, p. 2079 - 2083 (2007/10/03)
2-Methyl-1-substituted-imidazo[4,5-g]quinoline-4,9-diones and 7,8-dihydro-10H-[1,4]oxazino -[3',4':2,3]imidazo[4,5-g]quinoline-5,12-dione (19) derivatives have been synthesized from 6,7-dichloro-5,8-quinolinedione for developing the new anticancer drugs. Our study on the cytotoxicity of imidazoquinolinedione derivatives has revealed that 7,8-dihydro-10H-[1,4]oxazino-[3',4':2,3]imidazo[4,5-g]quinoline-5,12-dione (19), a tetracyclic heteroquinone analogue, exhibited high cytotoxicity on human colon tumor cell (HCT 15) in vitro SRB assay. The IC50 value of this compound was 0.026μg/mL whereas those of doxorubicin and cisplatin were 0.023μg/mL and 1.482μg/mL, respectively. Meanwhile compounds 5-7 and 12 in the series of 1-substituted-imidazoquinolinediones showed relatively good activity on human brain tumor cell lines (XF 498). Copyright (C) 2000 Elsevier Science Ltd.
