58377-57-4Relevant academic research and scientific papers
Rh(II)-catalyzed isomerization of 2-aryl-2H-azirines to 2,3-disubstituted indoles
Chiba, Shunsuke,Hattori, Gaku,Narasaka, Koichi
, p. 52 - 53 (2007)
Various 2,3-disubstituted indoles are synthesized by Rh 2(OCOCF3)4-catalyzed isomerization of 2-aryl-2H-azirines. Copyright
PREPARATION OF CHIRAL AMIDES AND AMINES
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Page/Page column 23, (2009/06/27)
This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.
