58379-80-9

Basic information

• Product Name: 1-METHYL-1-TOSYLMETHYL ISOCYANIDE
• Synonyms: 1-METHYL-1-TOSYLMETHYL ISOCYANIDE;1-(1-isocyanoethylsulfonyl)-4-methylbenzene;Benzene, 1-[(1-isocyanoethyl)sulfonyl]-4-methyl-;1-tosylethyl isocyanide;methyl-TOSMIC
• CAS NO: 58379-80-9
• Molecular Formula: C₁₀H₁₁NO₂S
• Molecular Weight: 209.26
• Mol File: 58379-80-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 46 °C
• Appearance: /
• CAS DataBase Reference: 1-METHYL-1-TOSYLMETHYL ISOCYANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1-TOSYLMETHYL ISOCYANIDE(58379-80-9)
• EPA Substance Registry System: 1-METHYL-1-TOSYLMETHYL ISOCYANIDE(58379-80-9)

Safety Data

• Hazardous Substances Data: 58379-80-9(Hazardous Substances Data)

Usage

General Description

1-Methyl-1-tosylmethyl isocyanide is a chemical compound with the molecular formula C11H13NO and a molecular weight of 175.23 g/mol. It is a highly reactive and potentially toxic compound that is used in organic synthesis as a building block for the preparation of various other compounds. It is characterized by its distinct isocyanide functional group, which makes it a valuable reagent for the formation of carbon-carbon and carbon-nitrogen bonds. Despite its reactivity and potential toxicity, 1-methyl-1-tosylmethyl isocyanide plays a crucial role in organic chemistry as a versatile reagent in the synthesis of pharmaceuticals and other complex organic molecules. Proper handling and safety precautions are necessary when working with this compound due to its hazardous nature.

InChI:InChI=1/C10H11NO2S/c1-8-4-6-10(7-5-8)14(12,13)9(2)11-3/h4-7,9H,1-2H3

Upstream product

• 58379-87-6 {1-[(4-methylphenyl)sulfonyl]ethyl}formamide 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 117267-31-9 1,3-bis(4-methyl-5-oxazolyl)benzene 
• 117267-32-0 1,4-bis(4-methyl-5-oxazolyl)benzene 
• 120286-63-7 1,4-bis<1-(4-bromophenyl)-4-methyl-imidazolyl>benzene 
• 97388-64-2 [4-Chloro-1-methyl-1-(toluene-4-sulfonyl)-butyl]-methylene-amine 
• 117267-30-8 1,2-bis(4-methyl-5-oxazolyl)benzene 
• 23012-24-0 4-methyl-5-(4-nitro-phenyl)-oxazole 
• 35833-97-7 3-bromo-2,5-dimethylpyrazolo[1,5-c]pyrimidine 
• 895637-39-5 4-Methyl-5-(3-nitrophenyl)-1,3-oxazole 
• 1444444-36-3 2,3-dihydro-2-methyl-2-[(4-methylphenyl)sulfonyl]-1H-inden-1-imine 
• 40611-76-5 methyl 5-methyl-1H-pyrrole-3-carboxylate 
• 1145661-62-6 2-[5-(4-bromo-phenyl)-4-methyl-imidazol-1-yl]-3,5-dichloro-pyridine 
• 1146695-73-9 5-(4-chloro-3-fluorophenyl)-4-methyloxazole 
• 1146695-66-0 2-methyl-2-(4-(4-methyloxazol-5-yl)phenyl)propanenitrile 
• 1146695-92-2 5-(3-chloro-4-(trifluoromethyl)phenyl)-4-methyloxazole 

Relevant articles and documents

INHIBITOR COMPOUNDS

The disclosure relates to heterocyclic compounds and methods for their preparation. The disclosure provides compounds that may have beneficial therapeutic activity in the treatment of a disease or condition mediated by excessive or otherwise undesirable Des1 and/or fibrotic activity.

ATR INHIBITOR AND APPLICATION THEREOF

Disclosed are a compound as an ATR inhibitor and an application in preparing a drug as an ATR inhibitor. In particular, disclosed is a compound represented by formula (I) or an isomer or pharmaceutically acceptable salt thereof.

Pd(II)-Catalyzed [4 + 2] Heterocyclization Sequence for Polyheterocycle Generation

A new Pd(II)-catalyzed cascade sequence for the formation of polyheterocycles, from simple starting materials, is reported. The sequence is applicable to both indole and pyrrole substrates, and a range of substituents are tolerated. The reaction is thought to proceed by a Pd(II)-catalyzed C-H activated Heck reaction followed by a second Pd(II)-catalyzed aza-Wacker reaction with two Cu(II)-mediated Pd(0) turnovers per sequence. The sequence can be considered a formal [4 + 2] heterocyclization.