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583840-04-4

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583840-04-4 Usage

Uses

N-Desmethyl Sorafenib (Pyridine)-N-oxide is a metabolite of Sorafenib (S676850) and has anti-proliferative activity in human breast cancer cells.

Check Digit Verification of cas no

The CAS Registry Mumber 583840-04-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,8,3,8,4 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 583840-04:
(8*5)+(7*8)+(6*3)+(5*8)+(4*4)+(3*0)+(2*0)+(1*4)=174
174 % 10 = 4
So 583840-04-4 is a valid CAS Registry Number.

583840-04-4Downstream Products

583840-04-4Relevant articles and documents

Aryl ureas as kinase inhibitors

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Page/Page column 21; 23, (2015/11/30)

This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VE

Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors

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, (2008/06/13)

This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality which is oxidized at the nitrogen heteroatom and which are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.

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