583867-13-4Relevant academic research and scientific papers
2,4-Dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists: Further characterization of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester and structure-activity relationships
Micheli, Fabrizio,Di Fabio, Romano,Bordi, Fabio,Cavallini, Palmina,Cavanni, Paolo,Donati, Daniele,Faedo, Stefania,Maffeis, Micaela,Sabbatini, Fabio Maria,Tarzia, Giorgio,Tranquillini, Maria Elvira
, p. 2113 - 2118 (2003)
Following the disclosure of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester [3,5-dimethyl PPP] as a potent and selective mGluR1 non-competitive antagonist, we report here further in vivo characterization of this important tool and disclose the investigation of the C-5 position, which led to very potent compounds.
