583873-69-2Relevant academic research and scientific papers
Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: Predicting enzyme conformational change and metabolism
Terasaka, Tadashi,Tsuji, Kiyoshi,Kato, Takeshi,Nakanishi, Isao,Kinoshita, Takayoshi,Kato, Yasuko,Kuno, Masako,Inoue, Takeshi,Tanaka, Kohichiro,Nakamura, Katsuya
, p. 4750 - 4753 (2005)
From metabolic considerations and prediction of an inhibitor-induced conformational change, novel adenosine deaminase (ADA) inhibitors with improved activities and oral bioavailability have been developed on the basis of our originally designed non-nucleo
