583883-92-5Relevant academic research and scientific papers
Synthesis of 5-(7-hydroxyheptyl)-1,2-dithiolan-3-one 1-oxide, a core functionality of antibiotic leinamycin
Lee, Alex H. F.,Chen, Jian,Chan, Albert S. C.,Li, Tianhu
, p. 1163 - 1174 (2003)
5-(7-Hydroxyheptyl)-1,2-dithiolan-3-one 1-oxide was designed and synthesized in our laboratories that contain the heterocycle of 1,2-dithiolan-3-one 1-oxide, a reactive core of antibiotic leinamycin. In addition, the activated ester of 5-(7-hydroxyheptyl)-1,2-dithiolan-3-one 1-oxide was prepared, which presumably is useful for coupling this DNA-cleaving functionality to certain DNA-binding agents.
