58393-52-5Relevant academic research and scientific papers
Preparation method of thiophosphate compounds
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Paragraph 0112-0118, (2017/08/30)
The invention provides a preparation method of thiophosphate compounds. The method comprises the following step: enabling P (O)-H compounds to react with a compound containing a mercapto functional group in an organic solvent in presence of inorganic base so as to obtain so as to obtain the thiophosphate compounds. According to the preparation method, the P (O)-H compounds are taken as initial raw materials, and a dehydrogenation coupling reaction is carried out in presence of the inorganic base under the conditions of metal-free catalysis and room temperature, so that high-yield thiophosphate or organic phosphate is synthesized; furthermore, the method has good applicability for alkyl phosphite or aryl phosphine oxide which has different substituent groups, and thiophenol. The synthetic route provided by the invention is simple in raw materials, mild in reaction conditions, short in reaction time, high in yield and less in by-products, is beneficial to post-synthesis of thiophosphate medicines having biological activity, reduces metal residue and toxic effects, and provides more directions and choices for the related applications in the aspects of medicines, pesticide and bioactive molecules.
