584-04-3Relevant articles and documents
Total synthesis of gymnorrhizol, an unprecedented 15-membered macrocyclic polydisulfide from the Chinese mangrove bruguiera gymnorrhiza
Gong, Jing-Xu,Shen, Xu,Yao, Li-Gong,Jiang, Hualiang,Krohn, Karsten,Guo, Yue-Wei
, p. 1715 - 1716 (2007)
The total synthesis of gymnorrhizol, a naturally occurring macrocyclic polydisulfide with a new skeleton and a potent proteintyrosinephosphatase 1B inhibitor, was prepared in three steps, starting from (R)-1-bromo-3- chloroisopropanol and 1,3-dichloropropan-2-ol.
A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model
Liu, Yaping,Ma, Huilong,Zhang, Liangwei,Cui, Yajing,Liu, Xiaoting,Fang, Jianguo
, p. 2296 - 2299 (2016)
The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.
Molecular rods based on oligo-spiro-thioketals
Wessig,Gerngro?,Freyse,Bruhns,Przezdziak,Schilde,Kelling
, p. 1125 - 1136 (2016/02/19)
We report on an extension of the previously established concept of oligospiroketal (OSK) rods by replacing a part or all ketal moieties by thioketals leading to oligospirothioketal (OSTK) rods. In this way, some crucial problems arising from the reversible formation of ketals are circumvented. Furthermore, the stability of the rods toward hydrolysis is considerably improved. To successfully implement this concept, we first developed a number of new oligothiol building blocks and improved the synthetic accessibility of known oligothiols, respectively. Another advantage of thioacetals is that terephthalaldehyde (TAA) sleeves, which are too flexible in the case of acetals can be used in OSTK rods. The viability of the OSTK approach was demonstrated by the successful preparation of some OSTK rods with a length of some nanometers.