58436-28-5Relevant articles and documents
Inhibition of LFA-1/ICAM-1-mediated cell adhesion by stilbene derivatives from Rheum undulatum
Lee, Seung Woong,Hwang, Byung Soon,Kim, Mi-Hwa,Park, Chan-Sun,Lee, Woo Song,Oh, Hyun-Mee,Rho, Mun-Chual
, p. 1763 - 1770 (2012)
Six stilbenes were isolated from the methanol extract of Rheum undulatum rhizomes by bioactivity- guided fractionation. The structures of the compounds were determined by spectroscopic analysis (1H-, 13C-NMR and MS), to be desoxyrhap
Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II)
Fukuhara, Kiyoshi,Nagakawa, Maki,Nakanishi, Ikuo,Ohkubo, Kei,Imai, Kohei,Urano, Shiro,Fukuzumi, Shunichi,Ozawa, Toshihiko,Ikota, Nobuo,Mochizuki, Masataka,Miyata, Naoki,Okuda, Haruhiro
, p. 1437 - 1443 (2006)
Resveratrol (1, 3,5,4′-trihydroxy-trans-stilbene), a polyphenol found in grapes and other food products, is known as an antioxidant and cancer chemopreventive agent. However, 1 was shown to induce genotoxicity through a high frequency of micronucleus and
Bibenzyls and dihydroisocoumarins from white salsify (Tragopogon porrifolius subsp. porrifolius)
Zidorn, Christian,Lohwasser, Ulrike,Pschorr, Susanne,Salvenmoser, Daniela,Ongania, Karl-Hans,Ellmerer, Ernst P.,Boerner, Andreas,Stuppner, Hermann
, p. 1691 - 1697 (2005)
A phytochemical investigation of three accessions of Tragopogon porrifolius L. subsp. porrifolius (Asteraceae, Lactuceae) yielded three new bibenzyl derivatives, 5,4′-dihydroxy-3-α-l-rhamnopyranosyl-(1→3)-β- d-xylopyranosyloxybibenzyl, 2-carboxyl-3,4′-dih
Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts
Birar, Vishal C.,Faragher, Richard G. A.,Ostler, Elizabeth L.,Sheerin, Angela N.
, p. 817 - 826 (2020/08/17)
Resveratrol alters the cytokinetics of mammalian cell populations in a dose dependent manner. Concentrations above 25–50 μM typically trigger growth arrest, senescence and/or apoptosis in multiple different cell types. In contrast, concentrations below 10 μM enhance the growth of log phase cell cultures and can rescue senescence in multiple strains of human fibroblasts. To better understand the structural features that regulate these effects, a panel of 24 structurally-related resveralogues were synthesised and evaluated for their capacity to activate SIRT1, as determined by an ex-vivo SIRT1 assay, their toxicity, as measured by lactate dehydrogenase release, and their effects on replicative senescence in MRC5 human fibroblasts as measured by their effects on Ki67 immunoreactivity and senescence-associated β galactosidase activity. Minor modifications to the parent stilbene, resveratrol, significantly alter the biological activities of the molecules. Replacement of the 3,5-dihydroxy substituents with 3,5-dimethoxy groups significantly enhances SIRT1 activity, and reduces toxicity. Minimising other strong conjugative effects also reduces toxicity, but negatively impacts SIRT1 activation. At 100 μM many of the compounds, including resveratrol, induce senescence in primary MRC5 cells in culture. Modifications that reduce or remove this effect match those that reduce toxicity leading to a correlation between reduction in labelling index and increase in LDH release. At 10 μM, the majority of our compounds significantly enhance the growth fraction of log phase cultures of MRC5 cells, consistent with the rescue of a subpopulation of cells within the culture from senescence. SIRT1 activation is not required for rescue to occur but enhances the size of the effect.
The skin care composition containing the same
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Paragraph 0018, (2019/12/12)
PROBLEM TO BE SOLVED: To provide an external preparation composition with tyrosinase activity inhibitory action for easily adding to skin external preparation, hydrogenated resveratrol useful as an active ingredient for skin external preparations such as