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58436-28-5

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  • China Largest factory Manufacturer Supply High Quality Dihydroresveratrol CAS 58436-28-5

    Cas No: 58436-28-5

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    Cas No: 58436-28-5

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58436-28-5 Usage

Description

Dihydroresveratrol (58436-28-5) is a metabolite of resveratrol produced by gut microbiota.1-3?Glucoronide conjugates are found in human urine after oral intake of resveratrol-containing dietary supplements.4?Dihydroresveratrol glucoside is a potent melanogenesis inhibitor in B16F0 melanoma cells.5?Inactive analog of resveratrol in induction of premature senescence.6

Uses

Different sources of media describe the Uses of 58436-28-5 differently. You can refer to the following data:
1. Dihydroresveratrol is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota. Dihydroresveratrol and dihydroresveratrol monosulfate are detectable in urine. The physiological effects of dihydroresveratrol have not been investigated.
2. Dihydroresveratrol is a natural phytoestrogen.

References

1) Jung?et al.?(2009),?Interaction of dietary resveratrol with animal-associated bacteria; FEMS Microbiol. Lett.,?297?266 2) Bode?et al.?(2013),?In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota; Am. J. Clin. Nutr.,?97?295 3) Jarosova?et al.?(2019),?Metabolism of Stilbenoids by Human Faecal Microbiota; Molecules,?24?E1155 4) Radco?et al.?(2013),?Semi-preparative isolation of dihydroresveratrol-3-O-?-d-glucuronide and four resveratrol conjugates from human urine after oral intake of a resveratrol-containing dietary supplement; J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 930?54 5) Oode?et al.?(2014),?Synthesis of dihydroresveratrol glycosides and evaluation of their activity against melanogenesis in B16F0 melanoma cells; Eur. J. Med. Chem.,?87?862 6) Faragher?et al.?(2011),?Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts; Age (Dordr.),?33?555

Check Digit Verification of cas no

The CAS Registry Mumber 58436-28-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,4,3 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 58436-28:
(7*5)+(6*8)+(5*4)+(4*3)+(3*6)+(2*2)+(1*8)=145
145 % 10 = 5
So 58436-28-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H14O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h3-9,15-17H,1-2H2

58436-28-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,3',5-trihydroxybibenzyl

1.2 Other means of identification

Product number -
Other names 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:58436-28-5 SDS

58436-28-5Relevant articles and documents

Inhibition of LFA-1/ICAM-1-mediated cell adhesion by stilbene derivatives from Rheum undulatum

Lee, Seung Woong,Hwang, Byung Soon,Kim, Mi-Hwa,Park, Chan-Sun,Lee, Woo Song,Oh, Hyun-Mee,Rho, Mun-Chual

, p. 1763 - 1770 (2012)

Six stilbenes were isolated from the methanol extract of Rheum undulatum rhizomes by bioactivity- guided fractionation. The structures of the compounds were determined by spectroscopic analysis (1H-, 13C-NMR and MS), to be desoxyrhap

Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II)

Fukuhara, Kiyoshi,Nagakawa, Maki,Nakanishi, Ikuo,Ohkubo, Kei,Imai, Kohei,Urano, Shiro,Fukuzumi, Shunichi,Ozawa, Toshihiko,Ikota, Nobuo,Mochizuki, Masataka,Miyata, Naoki,Okuda, Haruhiro

, p. 1437 - 1443 (2006)

Resveratrol (1, 3,5,4′-trihydroxy-trans-stilbene), a polyphenol found in grapes and other food products, is known as an antioxidant and cancer chemopreventive agent. However, 1 was shown to induce genotoxicity through a high frequency of micronucleus and

Bibenzyls and dihydroisocoumarins from white salsify (Tragopogon porrifolius subsp. porrifolius)

Zidorn, Christian,Lohwasser, Ulrike,Pschorr, Susanne,Salvenmoser, Daniela,Ongania, Karl-Hans,Ellmerer, Ernst P.,Boerner, Andreas,Stuppner, Hermann

, p. 1691 - 1697 (2005)

A phytochemical investigation of three accessions of Tragopogon porrifolius L. subsp. porrifolius (Asteraceae, Lactuceae) yielded three new bibenzyl derivatives, 5,4′-dihydroxy-3-α-l-rhamnopyranosyl-(1→3)-β- d-xylopyranosyloxybibenzyl, 2-carboxyl-3,4′-dih

Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts

Birar, Vishal C.,Faragher, Richard G. A.,Ostler, Elizabeth L.,Sheerin, Angela N.

, p. 817 - 826 (2020/08/17)

Resveratrol alters the cytokinetics of mammalian cell populations in a dose dependent manner. Concentrations above 25–50 μM typically trigger growth arrest, senescence and/or apoptosis in multiple different cell types. In contrast, concentrations below 10 μM enhance the growth of log phase cell cultures and can rescue senescence in multiple strains of human fibroblasts. To better understand the structural features that regulate these effects, a panel of 24 structurally-related resveralogues were synthesised and evaluated for their capacity to activate SIRT1, as determined by an ex-vivo SIRT1 assay, their toxicity, as measured by lactate dehydrogenase release, and their effects on replicative senescence in MRC5 human fibroblasts as measured by their effects on Ki67 immunoreactivity and senescence-associated β galactosidase activity. Minor modifications to the parent stilbene, resveratrol, significantly alter the biological activities of the molecules. Replacement of the 3,5-dihydroxy substituents with 3,5-dimethoxy groups significantly enhances SIRT1 activity, and reduces toxicity. Minimising other strong conjugative effects also reduces toxicity, but negatively impacts SIRT1 activation. At 100 μM many of the compounds, including resveratrol, induce senescence in primary MRC5 cells in culture. Modifications that reduce or remove this effect match those that reduce toxicity leading to a correlation between reduction in labelling index and increase in LDH release. At 10 μM, the majority of our compounds significantly enhance the growth fraction of log phase cultures of MRC5 cells, consistent with the rescue of a subpopulation of cells within the culture from senescence. SIRT1 activation is not required for rescue to occur but enhances the size of the effect.

The skin care composition containing the same

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Paragraph 0018, (2019/12/12)

PROBLEM TO BE SOLVED: To provide an external preparation composition with tyrosinase activity inhibitory action for easily adding to skin external preparation, hydrogenated resveratrol useful as an active ingredient for skin external preparations such as

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