58443-35-9

Upstream product

• 7654-06-0 3-phenyl-2H-azirine 
• 33251-20-6 1,4-diphenylbutane-1,2,4-trione 
• 5398-64-1 2-benzylidene-1,3-diphenylpropane-1,3-dione 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 

Relevant academic research and scientific papers

Synthesis of 3-(1,2-dioxoethyl)- and 2,3-dicarbonyl-containing pyrroles

The transition metal-catalyzed reaction of 2H-azirines with 1,2,4-tricarbonyl compounds leads to 3-(1,2-dioxoethyl)- and 2,3-dicarbonyl-pyrrole derivatives, useful building blocks for the preparation of 3-heterocyclyl pyrroles and pyrroles fused with heterocycles. The influence of catalysts and the reaction conditions on the yields of pyrroles and the regioselectivity of the reaction were studied. Experimental and theoretical results suggest that the reaction proceeds via the formation of an intermediate azirine-metal complex and subsequent nucleophilic N-C3 bond cleavage.

Tandem Michael addition/isocyanide insertion into the C-C bond: A novel access to 2-acylpyrroles and medium-ring fused pyrroles

A new reaction model, tandem Michael addition/formal isocyanide insertion into the acyl C-C bond, has been developed. Thus, a series of 2-acylpyrroles and seven-/eight-membered ring fused pyrroles were synthesized from the reaction of methyl isocyanides with enones in a single operation.