58457-37-7 Usage
Uses
Used in Pharmaceutical Industry:
1H-PYRROLO[3,2-H]QUINOLINE-2-CARBOXYLIC ACID is used as a pharmaceutical compound for its anti-inflammatory properties, helping to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
1H-PYRROLO[3,2-H]QUINOLINE-2-CARBOXYLIC ACID is used as an anti-tumor agent for its potential to inhibit tumor growth and progression, making it a candidate for cancer treatment.
1H-PYRROLO[3,2-H]QUINOLINE-2-CARBOXYLIC ACID is used as an anti-bacterial agent, exhibiting properties that can help combat bacterial infections.
Used in Immunology Research:
1H-PYRROLO[3,2-H]QUINOLINE-2-CARBOXYLIC ACID is used as a chemoattractant in immune response studies, aiding in the understanding of how immune cells are attracted to sites of infection or inflammation.
Used in Medicinal Chemistry Research:
1H-PYRROLO[3,2-H]QUINOLINE-2-CARBOXYLIC ACID is used as a target compound for further research and development in the field of medicinal chemistry, due to its unique structure and potential therapeutic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 58457-37-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,4,5 and 7 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 58457-37:
(7*5)+(6*8)+(5*4)+(4*5)+(3*7)+(2*3)+(1*7)=157
157 % 10 = 7
So 58457-37-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H8N2O2/c15-12(16)9-6-8-4-3-7-2-1-5-13-10(7)11(8)14-9/h1-6,14H,(H,15,16)
58457-37-7Relevant academic research and scientific papers
2-Substituted 1H-pyrrolo [3,2-h] quinoline derivatives: Synthesis and aspects of their biological activity
Grazia Ferlin,Chiarelotto,Baccichetti,Carlassare,Toniolo,Bordin
, p. 1513 - 1528 (2007/10/02)
Certain 2-substituted 1H-pyrrolo [3,2-h] quinolines have been prepared and their biological activity in mammalian cells and in some microrganisms have been studied. These compounds represent a simplified ellipticine heterocyclic moiety: in addition they have a different ring condensation, leading to an angular molecular structure instead of a linear one. In mammalian cells all compounds appeared to be able of inducing an antiproliferative effect and an extensive DNA fragmentation, similarly to ellipticine, even if to a reduced extent. The new derivatives behaved in a comparable way also on some microrganisms, such as T2 bacteriophage (which appears to be less sensitive than mammalian cells) and in mutagenesis tests carried out with E. coli WP2 TM9 and S. typhimurium TA 98, which are reverted by base substitution and frame-shift mutagens, respectively. Similarly to the reference compound, all ellipticine analogues appeared to be no mutagenic. The obtained results suggest that they induce the antiproliferative activity in mammalian cells mainly as topoisomerase inhibitors, similarly to ellipticine itself. Therefore, they represent an interesting model to design new potential anticancer drugs.
