58468-44-3Relevant academic research and scientific papers
Nickel catalyzed intramolecular oxidative coupling: synthesis of 3-aryl benzofurans
Aggarwal, Sakshi,Satyanarayana, Gedu,Sreenivasulu, Chinnabattigalla,Srinivas, Dasari
, p. 22264 - 22272 (2020/07/03)
Recent research has been focused on the transition metal-catalyzed reactions. Herein we have developed nickel-catalyzed synthesis of 3-aryl benzofurans fromortho-alkenyl phenolsviaintramolecular dehydrogenative coupling. Notably, simple O2gas served as an oxidant, without using any sacrificial hydrogen acceptor. The strategy enabled the synthesis of 3-aryl benzofurans in good to excellent yields.
Facile synthesis of 3-aryl benzofurans, 3-aryl benzothiophenes, 2-aryl indoles and their dimers
Umareddy, Pailla,Arava, Veera Reddy
supporting information, p. 2156 - 2167 (2019/07/04)
The preparation of 3-aryl benzofuran and benzothiophenes and their dimers at 2-position and, 2-aryl indoles and their 3-position dimers preparation is described.
Ga(OTf)3-mediated synthesis of substituted benzofurans
Wang, Heui-Sin,Chan, Chieh-Kai,Chang, Meng-Yang
, p. 5132 - 5141 (2016/07/25)
A synthetic procedure, for the synthesis of a series of functionalized benzofurans 3–5 and benzonaphthofurans 6, starting from intermolecular O-alkylation of α-bromoaryl ketones 2 with potassium oxygenated phenoxides 1 followed by Ga(OTf)3-catalyzed direct intramolecular cyclodehydration of the resulting α-aryloxyaryl ketones, has been developed. The use of various metal triflates was investigated for a facile approach and efficient transformation. Pentacyclic benzophenanthrofurans 7 were prepared via photolytic annulations of 5.
Novel one-pot synthesis of 3-Phenylnaphtho[2,3-b]furan and 3-phenylbenzofurans under microwave irradiation and solvent-free conditions
Wang, Zhongxing,Gu, Jinzhong,Jing, Huanwang,Liang, Yongmin
experimental part, p. 4079 - 4087 (2009/12/24)
A one-pot synthesis of functionalized benzofurans has been developed via O-alkylation, carbon-carbon coupling/cyclization, and dehydration/olefination tandem reactions from phenacyl bromide and phenols under microwave irradiation and solvent-free conditio
Palladium(II)-catalyzed intramolecular addition of arylboronic acids to ketones
Liu, Guixia,Lu, Xiyan
, p. 7324 - 7330 (2008/12/20)
A palladium(II)-catalyzed intramolecular addition of arylboronic acids to ketones was developed. Compared to Pd(OAc)2 catalysis system, cationic palladium complex with dppp as the ligand has higher catalytic activity and efficiency for wider sc
BCl3-promoted synthesis of benzofurans
Kim, Ikyon,Lee, Sei-Hee,Lee, Sunkyung
scheme or table, p. 6579 - 6584 (2009/04/06)
Lewis acidic nature of boron trichloride (BCl3) to coordinate to the carbonyl functionality was exploited for the synthesis of benzofurans via dehydrative cyclization. This mild and efficient procedure allowed for facile access to a number of h
Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities
Mahindroo, Neeraj,Huang, Chien-Fu,Peng, Yi-Huei,Wang, Chiung-Chiu,Liao, Chun-Chen,Lien, Tzu-Wen,Chittimalla, Santhosh Kumar,Huang, Wei-Jan,Chai, Chia-Hua,Prakash, Ekambaranellore,Chen, Ching-Ping,Hsu, Tsu-An,Peng, Cheng-Hung,Lu, I-Lin,Lee, Ling-Hui,Chang, Yi-Wei,Chen, Wei-Cheng,Chou, Yu-Chen,Chen, Chiung-Tong,Goparaju, Chandra M. V.,Chen, Yuan-Shou,Lan, Shih-Jung,Yu, Ming-Chen,Chen, Xin,Chao, Yu-Sheng,Wu, Su-Ying,Hsieh, Hsing-Pang
, p. 8194 - 8208 (2007/10/03)
The synthesis and structure-activity relationship studies of novel indole derivatives as peroxisome proliferator-activated receptor (PPAR) agonists are reported. Indole, a druglike scaffold, was studied as a core skeleton for the acidic head part of PPAR
Halogen-metal exchange/cyclization of iodoketones: A direct synthesis of 3-arylbenzofurans
Kraus, George A.,Schroeder, Jacob D.
, p. 2504 - 2506 (2007/10/03)
The first synthesis of benzofuran 2 was achieved in 17% overall yield in seven steps. The key step was a halogen-metal exchange/cyclization reaction. Several examples of this reaction were reported. Georg Thieme Verlag Stuttgart.
Phenylacetic acid derivatives as hPPAR agonists
Santini, Conrad,Berger, Gregory D.,Han, Wei,Mosley, Ralph,MacNaul, Karen,Berger, Joel,Doebber, Thomas,Wu, Margaret,Moller, David E.,Tolman, Richard L.,Sahoo, Soumya P.
, p. 1277 - 1280 (2007/10/03)
Beginning with the weakly active lead structure 1, a new series of hPPAR agonists was developed. In vivo glucose and triglyceride lowering activity was obtained by homologation and oxamination to 3, then conversion to substituted benzisoxazoles 4 and 5. F
