58472-30-3Relevant academic research and scientific papers
The role of new technologies in defining a manufacturing process for ppara agonist ly518674
Argentine, Mark D.,Braden, Timothy M.,Czarnik, Jeffrey,Conder, Edward W.,Dunlap, Steven E.,Fennell, Jared W.,LaPack, Mark A.,Rothhaar, Roger R.,Scherer, R. Brian,Schmid, Christopher R.,Vicenzi, Jeffrey T.,Wei, Jeffrey G.,Werner, John A.,Roginski, Robert T.
supporting information; experimental part, p. 131 - 143 (2010/04/22)
The impact of several new technologies on the development of a manufacturing process for LY518674 is described. Extensive use of process analytical technology (PAT) throughout development, both at laboratory and pilot-plant scale, enabled data-rich experi
Synthesis and antiallergic activity of 2 hydroxy 3 nitro 1,4 naphthoquinones
Buckle,Cantello,Smith,Spicer
, p. 1059 - 1064 (2007/10/06)
A selection of novel 2-hydroxy-3-nitro-1,4-naphthoquinones are shown to be potent inhibitors of rat passive cutaneous anaphylaxis (PCA) and to have highest potency with alkyl substitution at both C-6 and C-7. The most potent compounds were 7c and 7e which produced a 50% inhibition in the rat PCA test at doses of about 10 μM/kg following subcutaneous administration and showed activity after oral administration. Related 4-hydroxy-3-nitro-2(1H)-naphthalenones had no effect on rat PCA in doses up to 500 μM/kg.
