58477-93-3

Basic information

• Product Name: 1-(3-aMinopropoxy)naphthalene
• Synonyms: 1-(3-aMinopropoxy)naphthalene;3-(Naphthalen-1-yloxy)propan-1-aMine;3-(1-naphthalenyloxy)-1-Propanamine
• CAS NO: 58477-93-3
• Molecular Formula: C13H15NO
• Molecular Weight: 201.2643
• Mol File: 58477-93-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3-aMinopropoxy)naphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-aMinopropoxy)naphthalene(58477-93-3)
• EPA Substance Registry System: 1-(3-aMinopropoxy)naphthalene(58477-93-3)

Safety Data

• Hazardous Substances Data: 58477-93-3(Hazardous Substances Data)

Usage

General Description

1-(3-aminopropoxy)naphthalene, also known as beta-naphthyl-3-propylamine, is a chemical compound with the molecular formula C12H15NO. It is a member of the naphthalene family and is classified as an aromatic amine. 1-(3-aMinopropoxy)naphthalene is used in organic synthesis and in the production of pharmaceuticals, dyes, and other chemical products. It is also used in research as a building block for more complex molecules. 1-(3-aminopropoxy)naphthalene has a strong odor and is a colorless to pale yellow liquid at room temperature. It is important to handle this chemical with care as it can be toxic and irritating to the skin, eyes, and respiratory system.

Upstream product

• 90-15-3 α-naphthol 
• 102196-49-6 2-[3-(naphthalen-1-yloxy)propyl]-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

N-(Phthalimidoalkyl) Derivatives of Serotonergic Agents: A Common Interaction at 5-HT1A Serotonin Binding Sites ?

Several classes of agents are known to bind at central 5-HT1a serotonin sites.In order to challenge the hypothesis that these agents bind in a relatively similar manner (i.e., share common aryl and terminal amine sites), we prepared N-(phthalimidobutyl) derivatives of examples of several such agents.With regard to arylpiperazines, we had previously shown that introduction of this functionality at the terminal amine is tolerated by the receptor and normally results in a significant (>10-fold) enhancement in affinity.The results of the present study show that this bulky functionality is also tolerated by the receptor when incorporated into examples of all other major classes of 5-HT1A agents (e.g., 2-aminotetralin, phenylalkylamine, indolylalkylamine, and (aryloxy)alkylamine derivatives).The length of the alkyl chain that separates the terminal amine from the phthalimido group is of major importance, and a four-carbon chain appears optimal.Alteration of the length of this chain can have a significant influence on affinity; decreasing the chain length from four to three carbon atoms can reduce affinity by an order of magnitude, and further shortening can have an even more pronounced effect.