58479-52-0Relevant articles and documents
One-pot N-dealkylation and acid-catalyzed rearrangement of morphinans into aporphines
Berényi, Sándor,Gyulai, Zsuzsanna,Udvardy, Antal,Sipos, Attila
body text, p. 1196 - 1198 (2010/04/25)
The one-pot N-demethylation and acid-catalyzed rearrangement of morphinan-N-oxides offers a new, shorter and more efficient route to neuropharmacologically important N-substituted aporphines. An improved procedure is described for the preparation of the starting alkaloid N-oxides using Na2WO4 as catalyst. The transetherification during the rearrangement of codeinone into 2-O-alkyl-norapocodeines is documented.
Aporphines. 35. Synthesis of (R)-(-)- and (S)-(+)-Apomorphine from Thebaine and (+)-Bulbocapnine
Ram, Vishnu J.,Neumeyer, John L.
, p. 2830 - 2831 (2007/10/02)
A practical method for the synthesis of (-)-apomorphine and (-)-N-n-propylnorapomorphine from the opioid thebaine is presented.The method is also applicable to the transformation of (+)-bulbocapnine to (+)-apomorphine.