5848-27-1

Usage

InChI:InChI=1/C11H9N3O2S/c1-5-3-7-8(4-6(5)2)17-11-13-9(15)12-10(16)14(7)11/h3-4H,1-2H3,(H,12,15,16)

Upstream product

• 75-31-0 isopropylamine 
• 10191-60-3 dimethyl N-cyanodithioiminocarbonate 
• 2253-73-8 isopropyl isothiocyanate 
• 19981-17-0 sodium cyanamide 

Downstream Products

• 59566-68-6 1-isopropyl-2-methyl-3-(4-oxo-6-phenyl-4H-[1,3,5]thiadiazin-2-yl)-isothiourea 
• 60201-98-1 1-isopropyl-2-methyl-3-(3-phenyl-[1,2,4]oxadiazol-5-yl)-isothiourea 
• 74-93-1 methylthiol 
• 106580-60-3 N³-Isopropyl-1H-[1,2,4]triazole-3,5-diamine 
• 44830-55-9 3-cyano-1-isopropylguanidine 
• 500-92-5 proguanil 
• 37557-98-5 1-isopropyl-5-phenyl-biguanide 
• 457-84-1 1-isopropyl-5-(4-fluorophenyl)biguanide 
• 537-78-0 1-(4-bromo-phenyl)-5-isopropyl-biguanide 

Relevant academic research and scientific papers

Benzene-sulphonamide derivatives and their uses

Benzene-sulphonamide derivatives complying with the general formula (I): in which the different symbols have different meanings, their optical isomers and the salts pharmacologically acceptable of these derivatives, as well as their uses for drug manufacture and as radiolabelled pharmacological tools of the thromboxan A2 receptors.

Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 μM, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as patent as their parent on insulin secretion.

First synthesis of 4-substituted benzenesulfonylcyanoguanidines

N'-substituted-N-cyano-S-methylcarbamimidothioates react with 4-substituted benzene sulfonamides to give the corresponding sulfonylcyanoguanidines.