58486-35-4Relevant academic research and scientific papers
Total Synthesis of (+)-Iresin
Wang, Bian-Lin,Gao, Hai-Tao,Li, Wei-Dong Z.
, p. 5296 - 5301 (2015)
The first asymmetric total synthesis of (+)-iresin (4), an historically important ent-Drimane sesquiterpene lactone, was realized from aldehyde 3 via cyclic orthoester 6 in 5 steps. Notable transformations in this synthesis include a tandem trifluoroperacetic acid (TFPAA)-mediated Baeyer-Villiger oxidation-olefin epoxidation-epoxy ester cyclization, regioselective Burgess dehydration, and regioselective Fétizon oxidative lactonization. (Chemical Equation Presented).
