58489-85-3

Upstream product

• 53107-37-2 1-(2,3-dichloro-4-methoxyphenyl)-2-methylene-1-propanone 
• 53107-35-0 2',3',-Dichloro-4'-methoxyisobutyrophenone 
• 1984-59-4 2,3-dichloroanisole 
• 54196-91-7 6,7-dichloro-5-methoxy-2-methyl-1-indanone 
• 58489-84-2 2-(4-chlorophenyl)-2-methyl-5-methoxy-6,7-dichloro-1-indanone 

Relevant academic research and scientific papers

(1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio) alkanoic acids, and derivatives thereof

[1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio)]aklanoic acid, derivatives thereof, their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. Also disclosed are processes for the preparation of such [1-oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio)]alkanoic acids, pharmaceutical compositions comprising therapeutically effective amounts of such compounds and methods of treatment comprising administering such compounds and compositions.

[1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic acids

[1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a 1-oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids or derivatives thereof with hydroxylamine in the presence of a base.