5849-35-4Relevant academic research and scientific papers
Selective Substitution of POCl 3 with Organometallic Reagents: Synthesis of Phosphinates and Phosphonates
Verbelen, Bram,Dehaen, Wim,Binnemans, Koen
, p. 2019 - 2026 (2018)
The selectivity of the substitution reaction of phosphoryl chloride with organometallic reagents was investigated using NMR spectroscopy. This led to the discovery that the selectivity of the substitution reaction can be tuned by choosing a proper organometallic reagent. A phosphinate could be obtained by using a Grignard reagent whereas an organozinc reagent provided a phosphonate. Based on these results, one-pot synthetic methods for the preparation of phosphinates and phosphonates using commercially available starting materials were developed. Both methods allow the synthesis of a broad range of either phosphinate or phosphonate derivatives in a straightforward and general procedure. Moreover, using these one-pot procedures, mixed systems substituted with different alkyl/aryl groups can be prepared.
INVESTIGATION OF THE REACTION BETWEEN DIALKYLPHOSPHINE OXIDES AND CARBONTETRACHLORIDE
Aksnes, Gunnar,Majewski, Piotr
, p. 261 - 274 (2007/10/02)
The time dependent formation of intermediates and end products in the reaction between Et2P(O)H and CCl4 is analysed using (31)P-NMR technique.The various reaction steps are studied separately in order to elucidate the overall mechanism.A key step is the disproportionation of Et2P(O)H catalysed by Et2PCl and Et2P(O)Cl, in a cyclic process, the latter being produced initially by the reaction between Et2P(O)H and CCl4.The diethylphosphine formed during disproportionation reacts immediately with CCl4, driving the reaction through the intermediates, Et2PCl and Et2PCCl3which react with Et2P(O)OH producing Et2P(O)Cl, (Et2PO)2O, and Et2P(O)CHCl2, as end products.The influence of the substituents on rate and product yields was studied with n-propyl, n-butyl, n-octyl, and allyl as substituents in the dialkylphosphine oxide.
