58490-71-4Relevant academic research and scientific papers
Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressants
Bhandari, Kalpana,Srivastava, Shipra,Shankar, Girija
, p. 4189 - 4196 (2007/10/03)
A series of thiourea derivatives (7-23, 25-27) of 1- aminotetrahydronaphthalene (4) and 1-amino-2-hydroxytetrahydronaphthalene (5) were synthesized in single pot in 48-90% yield and evaluated for their anorexigenic activity. Among them compounds 10, 14, 15, 16 and 22 exhibited significant anorexigenic activity without any antidepressant effect and provided a new structural lead for appetite suppressants.
