5851-51-4

Usage

Uses

Used in Organic Chemistry:
1H-Benzimidazole, 2-undecylis used as a chemical intermediate for the synthesis of various organic compounds. Its unique structure and properties make it a valuable building block in the development of new organic molecules.
Used in Pharmaceuticals:
1H-Benzimidazole, 2-undecylis used as a potential pharmaceutical candidate due to its structural similarity to benzimidazole, which is known to have various biological activities. It may be used in the development of new drugs targeting specific diseases or conditions.
Used in Research:
1H-Benzimidazole, 2-undecylis used as a research compound to study the properties and behavior of benzimidazole derivatives. This can help scientists gain a better understanding of the structure-activity relationships and potential applications of these compounds in various fields.

Upstream product

• 111-82-0 methyl n-dodecanoate 
• 95-54-5 1,2-diamino-benzene 
• 106-33-2 ethyl laurate 

Relevant academic research and scientific papers

New potential antitumor quinazolinones derived from dynamic 2-undecyl benzoxazinone: Synthesis and cytotoxic evaluation

Since the quinazoline and its derivatives have been considered as a novel class of cancer chemotherapeutic agents that show promising activity against different tumors, a new series of 6-iodo-2-undecylquinazolin-4(3H)-ones were prepared via reaction of 6-iodo-2-undecyl-4H-benzoxazin-4-one with nitrogen nucleophiles, namely, primary amines, 4-amino antipyrine, hydrazine hydrate, diamines, ethanol amine, and/or hydrazide derivatives and screened for their antitumor activity in vitro against a panel of three human tumor cell lines namely; hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, and mammary gland breast MCF-7. Compounds 14, 16, and 18 showed remarkable broad spectrum antitumor activity. All compounds were fully characterized by means of IR, MS, and 1H-NMR spectra.

Enzyme-mediated domino synthesis of 2-alkylbenzimidazoles in solvent-free system: A green route to heterocyclic compound

Solvent-free domino acylation/cyclization reactions between fatty acid esters and o-phenylenediamine mediated by immobilized lipase from Mucor miehei (MML) were found to be an efficient way in the synthesis of 2- alkylbenzimidazole. Compared with other substrates, methyl fatty acid esters with moderated chain length exhibited best activity with yield up to 95%. The mechanism of the domino process was clarified deeply through some detail experiments, including separation of intermediates. This efficient enzymatic domino process provides an attractive procedure for heterocyclic compound synthesis and could be regarded as a potential synthetic method in modern organic chemistry.