58511-19-6

Basic information

• Product Name: Acetic acid, [[(4-methylphenyl)methyl]sulfonyl]-
• CAS NO: 58511-19-6
• Molecular Formula: C10H12O4S
• Molecular Weight: 228.269
• Mol File: 58511-19-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetic acid, [[(4-methylphenyl)methyl]sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [[(4-methylphenyl)methyl]sulfonyl]-(58511-19-6)
• EPA Substance Registry System: Acetic acid, [[(4-methylphenyl)methyl]sulfonyl]-(58511-19-6)

Safety Data

• Hazardous Substances Data: 58511-19-6(Hazardous Substances Data)

Upstream product

• 58511-20-9 ((4-methylbenzyl)sulfanyl)acetic acid 
• 104-82-5 4-Methylbenzyl chloride 

Downstream Products

• 850133-64-1 p-tolylmethanesulfonyl-acetic acid hydrazide 
• 836610-61-8 N-(2-hydroxy-ethyl)-2-p-tolylmethanesulfonyl-acetamide 
• 836610-67-4 N-(2-chloro-ethyl)-2-p-tolylmethanesulfonyl-acetamide 
• 127936-70-3 p-tolylmethanesulfonyl-acetic acid methyl ester 
• 31355-12-1 4-Methylbenzyl-dijodmethyl-sulfon 

Relevant articles and documents

Design, synthesis and preliminary biological evaluation of benzylsulfone coumarin derivatives as anti-cancer agents

In this work, a series of benzylsulfone coumarin derivatives 5a-5o were synthesized and characterized. Kinase inhibitory activity assay indicated that most of the compounds showed considerable activity against PI3K. Anti-tumor activity studies of the active compounds were also carried out in vitro on the Hela, HepG2, H1299, HCT-116, and MCF-7 tumor cell lines by MTS assay. The structure-activity relationships (SARs) of these compounds were analyzed in detail. Compound 5h exhibited the most potent activities against the mentioned cell lines with IC50 values ranging from 18.12 to 32.60 μM, followed by 5m with IC50 values of 29.30-42.14 μM. Furthermore, 5h and 5m clearly retarded the migration of Hela cells in vitro. Next, an in silico molecular docking study was conducted to evaluate the binding models of 5h and 5m towards PI3Kαand PI3Kβ. Collectively, the above findings suggested that compounds 5h and 5m might be promising PI3K inhibitors deserving further investigation for cancer treatment.

Synthesis and antioxidant activity of 1,4-[Bis(3-arylmethanesulfonyl pyrrolyl and pyrazolyl)]benzenes

A variety of (1,4-phenylene)bis(arylmethanesulfonylpyrroles and pyrazoles) were prepared by the cycloaddition of 1,3-dipolar reagents, tosylmethyl isocyanide and diazomethane to the Michael acceptor, 1,4-bis(E)-2- ((arylmethanesulfonyl)vinyl)benzene. All the compounds were evaluated for antioxidant activity. Amongst the tested compounds, one of them displayed excellent radical scavenging activity in all the three methods evaluated when compared with the standard Ascorbic acid. On the other hand, 1,4-(bis(3-arylmethanesulfonyl)-1H-pyrazol-4-yl)benzenes exhibited comparatively higher antioxidant activity than 1,4-(bis(3-arylmethanesulfonyl)-1H-pyrrol-4- yl) benzenes. In general, it was observed that compounds having methoxy substitutent on aromatic ring displayed greater antioxidant activity than the other substituents. ?2014 Sociedade Brasileira de Qui?mica.