5852-92-6

Usage

Uses

Used in Pharmaceutical Research:
1,2-DIMETHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE is used as a research compound for studying neurotransmitters and central nervous system function. Its potential as a therapeutic agent for various neurological disorders has been recognized, with ongoing research into its anticonvulsant and analgesic properties.
Used in Neurological Disorder Treatment:
In the field of neurology, 1,2-DIMETHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE is used as a potential therapeutic agent for the treatment of various neurological disorders. Its specific applications are still under investigation, but the compound's effects on neurotransmission and central nervous system function are of particular interest.
Used in Research and Development:
1,2-DIMETHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE is utilized in research and development for the creation of new pharmaceuticals and therapeutic agents. Its unique chemical structure and properties make it a valuable tool in the discovery and optimization of novel treatments for a range of conditions.

InChI:InChI=1/C13H19NO2/c1-9-11-8-13(16-4)12(15-3)7-10(11)5-6-14(9)2/h7-9H,5-6H2,1-4H3/p+1/t9-/m1/s1

Upstream product

• 4721-98-6 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline 
• 17104-28-8 1-methyl-6,7-dimethoxy-2-methyl-3,4-dihydro-isoquinolinium iodide 

Relevant academic research and scientific papers

Potential cancer chemopreventive activity of simple isoquinolines, 1-benzylisoquinolines, and protoberberines

Seventeen simple isoquinolines, 15 1-benzylisoquinolines, and 19 protoberberines were tested for their inhibitory activities against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol- 13-acetate (TPA) in Raji cells. Among the tested alkaloids, the inhibitory activity of all 1-benzylisoquinolines and 11 protoberberines was higher than that of β-carotene. The 1-benzylisoquinolines 19, 21, 22, 29, and 34 and protoberberines 41, 47-49, 51, 52, and 55 showed potent inhibitory effects on EBV-EA induction (96-100% inhibition at 1 × 103 mol ratio/TPA). These alkaloids were more active than the naturally occurring alkaloids, 23, 25, 33, 53, and 54. In addition, fifteen simple isoquinolines, eighteen 1-benzylisoquinolines and eight protoberberines were evaluated with respect to their ability to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals. Nine simple isoquinolines, ten 1-benzylisoquinolines, and four protoberberines were more potent than α-tocopherol, and four 1-benzylisoquinolines, 20 and 28-30, exhibited potent activities (SC50 4.5-5.8 μM). Their activities were higher than the naturally occurring alkaloids, 23, 25, and 33. Therefore, some of the isoquinoline alkaloids indicating the high activity on both assays may be potentially valuable cancer chemopreventive agents. Structure-activity relationships are discussed for both tests.