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1-(3-deoxypentofuranosyl)cytosine, also known as 3'-deoxy-3'-azido-thymidine (AZT), is a nucleoside reverse transcriptase inhibitor (NRTI) used as an antiviral medication to treat HIV/AIDS. It works by inhibiting the activity of reverse transcriptase, an enzyme required by the HIV virus to replicate its genetic material. AZT is a synthetic nucleoside analog that mimics the natural nucleoside thymidine, but with a crucial difference: it lacks a 3'-hydroxyl group and contains an azido group instead. This modification prevents the viral DNA chain from extending, effectively halting the replication process. AZT was the first antiretroviral drug approved for the treatment of HIV and has played a significant role in the development of combination therapies that have transformed HIV/AIDS into a manageable chronic condition.

58526-07-1

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58526-07-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 58526-07-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,5,2 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 58526-07:
(7*5)+(6*8)+(5*5)+(4*2)+(3*6)+(2*0)+(1*7)=141
141 % 10 = 1
So 58526-07-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-6(14)3-5(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)

58526-07-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3-deoxy-β-D-threo-pentofuranosyl)cytosine

1.2 Other means of identification

Product number -
Other names 1-(3-deoxy-β-D-arabinofuranosyl)cytosine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:58526-07-1 SDS

58526-07-1Relevant academic research and scientific papers

The Synthesis of 2',3'-Dideoxycytidine and Its 2'-Azido Analogue. Applications of the Deoxygenative -Hydride Shift of Sulfonates with Mg(OMe)2-NaBH4

Kawana, Masajiro,Yamasaki, Noritsugu,Nishikawa, Masahiro,Kuzuhara, Hiroyoshi

, p. 2419 - 2422 (1987)

New synthetic routes to the title compounds from cytidine were developed.Key intermediates were prepared by the deoxygenative reduction of 3'-O-mesylcytidine derivatives with the title reagents in a one-pot procedure.

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