58534-63-7

Basic information

• Product Name: 4-(acetyloxy)-2-hydroxybenzoic acid
• CAS NO: 58534-63-7
• Molecular Formula: C₉H₈O₅
• Molecular Weight: 196.1568
• Mol File: 58534-63-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 370.9°C at 760 mmHg
• Flash Point: 152.4°C
• Density: 1.421g/cm³
• Vapor Pressure: 3.7E-06mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 4-(acetyloxy)-2-hydroxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(acetyloxy)-2-hydroxybenzoic acid(58534-63-7)
• EPA Substance Registry System: 4-(acetyloxy)-2-hydroxybenzoic acid(58534-63-7)

Safety Data

• Hazardous Substances Data: 58534-63-7(Hazardous Substances Data)

Upstream product

• 89-86-1 4-hydroxysalicylic acid 
• 108-24-7 acetic anhydride 
• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 150-19-6 O-methylresorcine 
• 102-29-4 Resorcinol monoacetate 
• 106315-78-0 methyl 2,4-diacetoxybenzoate 

Downstream Products

• 855875-90-0 3,5-diacetyl-2,4-dihydroxy-benzoic acid 
• 6883-54-1 5-acetyl-2,4-dihydroxy-benzoic acid methyl ester 
• 119014-22-1 4-acetoxy-2-(tetra-O-acetyl-β-D-glucopyranosyloxy)-benzoic acid ethyl ester 
• 122147-21-1 4-acetoxy-2-(tetra-O-acetyl-β-D-glucopyranosyloxy)-benzoic acid methyl ester 
• 184591-40-0 2-β-D-glucopyranosyloxy-4-hydroxy-benzoic acid propyl ester 
• 108972-36-7 2-β-D-glucopyranosyloxy-4-hydroxy-benzoic acid ethyl ester 
• 108125-73-1 2-β-D-glucopyranosyloxy-4-hydroxy-benzoic acid methyl ester 
• 77008-88-9 4-Acetoxy-2-hydroxybenzoesaeure-4-nitrophenylester 
• 62908-65-0 2,4-dihydroxy-5-acetylbenzoic acid 
• 103987-54-8 4-acetoxy-2-hydroxy-benzoic acid ethyl ester 
• 540527-11-5 methyl 4-acetoxy-2-hydroxybenzoate 

Relevant articles and documents

Cleavage of Carboxylic Esters by Aluminum and Iodine

A one-pot procedure for deprotecting carboxylic esters under nonhydrolytic conditions is described. Typical alkyl carboxylates are readily deblocked to the carboxylic acids by the action of aluminum powder and iodine in anhydrous acetonitrile. Cleavage of lactones affords the corresponding ω-iodoalkylcarboxylic acids. Aryl acetylates undergo deacetylation with the participation of the neighboring group. This method enables the selective cleavage of alkyl carboxylic esters in the presence of aryl esters.

PHARMACEUTICAL COMBINATIONS

The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group -(O)n-R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The combinations have activity as Hsp90 and/or glycogen synthase kinase-3 and/or cyclin dependent kinase inhibitors.

A New Method for the Degradation of Anthocyanidins, Flavones, Chalcones, and Coumarins

After transformation into the corresponding chalcone or flavenol acetates anthocyanidins are oxidatively cleaved with ruthenium tetroxide to yield benzoic acid derivatives of the rings A and B.Flavones, chalcones, and coumarins are degradated by the same method.