58534-63-7

Upstream product

• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 108-24-7 acetic anhydride 
• 102-29-4 Resorcinol monoacetate 
• 106315-78-0 methyl 2,4-diacetoxybenzoate 
• 150-19-6 O-methylresorcine 
• 89-86-1 4-hydroxysalicylic acid 

Downstream Products

• 540527-11-5 methyl 4-acetoxy-2-hydroxybenzoate 
• 103987-54-8 4-acetoxy-2-hydroxy-benzoic acid ethyl ester 
• 77008-88-9 4-Acetoxy-2-hydroxybenzoesaeure-4-nitrophenylester 
• 108125-73-1 2-β-D-glucopyranosyloxy-4-hydroxy-benzoic acid methyl ester 
• 108972-36-7 2-β-D-glucopyranosyloxy-4-hydroxy-benzoic acid ethyl ester 
• 184591-40-0 2-β-D-glucopyranosyloxy-4-hydroxy-benzoic acid propyl ester 
• 122147-21-1 4-acetoxy-2-(tetra-O-acetyl-β-D-glucopyranosyloxy)-benzoic acid methyl ester 
• 119014-22-1 4-acetoxy-2-(tetra-O-acetyl-β-D-glucopyranosyloxy)-benzoic acid ethyl ester 
• 6883-54-1 5-acetyl-2,4-dihydroxy-benzoic acid methyl ester 
• 855875-90-0 3,5-diacetyl-2,4-dihydroxy-benzoic acid 
• 62908-65-0 2,4-dihydroxy-5-acetylbenzoic acid 

Relevant academic research and scientific papers

Cleavage of Carboxylic Esters by Aluminum and Iodine

A one-pot procedure for deprotecting carboxylic esters under nonhydrolytic conditions is described. Typical alkyl carboxylates are readily deblocked to the carboxylic acids by the action of aluminum powder and iodine in anhydrous acetonitrile. Cleavage of lactones affords the corresponding ω-iodoalkylcarboxylic acids. Aryl acetylates undergo deacetylation with the participation of the neighboring group. This method enables the selective cleavage of alkyl carboxylic esters in the presence of aryl esters.

General method for the synthesis of salicylic acids from phenols through palladium-catalyzed silanol-directed C-H carboxylation

A silanol-directed, palladium-catalyzed C-H carboxylation reaction of phenols to give salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional-group tolerance. The generality of this method was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o′-disubstituted phenolic compound through two sequential C-H functionalization processes.

PHARMACEUTICAL COMBINATIONS

The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group -(O)n-R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The combinations have activity as Hsp90 and/or glycogen synthase kinase-3 and/or cyclin dependent kinase inhibitors.

Medicaments for the selective treatment of tumor tissues

Medicinal products for the selective control of tumor tissue and a method for control of such tumor tissue by administration of such product to a host. The products comprise: (a) two different compounds having a pH below 7 when the compounds are present i

A New Method for the Degradation of Anthocyanidins, Flavones, Chalcones, and Coumarins

After transformation into the corresponding chalcone or flavenol acetates anthocyanidins are oxidatively cleaved with ruthenium tetroxide to yield benzoic acid derivatives of the rings A and B.Flavones, chalcones, and coumarins are degradated by the same method.