585509-88-2

Usage

Physical state

Clear, colorless to pale yellow liquid

Solubility

Insoluble in water, soluble in organic solvents

Uses

Organic synthesis (introducing iodo group onto aromatic compounds), intermediate in production of pharmaceuticals, agrochemicals, and other organic compounds

Hazard classification

Toxic and irritating properties, requires careful handling and storage

Upstream product

• 762-72-1 allyl-trimethyl-silane 

Downstream Products

• 585509-89-3 1-Benzyloxy-3-isopropoxy-benzene 
• 68792-12-1 3-isopropoxyphenol 

Relevant academic research and scientific papers

Synthesis of complex ortho-allyliodoarenes by employing the reductive iodonio-claisen rearrangement

The reductive iodonio-Claisen rearrangement (RICR), involving complex aromatic λ3-iodanes and allyltrimethylsilane, was investigated. The RICR reaction of complex substituted aromatic hypervalent iodine (III) compounds and an allylmetal partner was conducted. The anionic oxy Cope rearrangement was found to be approximately 1010 to 1017 times faster than the neutral oxy Cope rearrangement due to weakening of the adjacent C-C bond by the oxygen anion. The results also indicate that the steric and electronic nature of the aromatic λ3-iodanes is the dominant factor influencing the [3,3]-sigmatropic rearrangement reaction. The removal of tert-butyl ether protecting group by using trifluroacetic acid in dichloromethane in the presence of triisopropylsilane gives the natural product broussin in 39% yield.

New compounds, pharmaceutical compositions and uses thereof

The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

NOVEL HETEROCYCLIC AMIDE DERIVATIVES HAVING DIHYDROOROTATE DEHYDROGENASE INHIBITING ACTIVITY

Novel heterocyclic amide derivatives having pharmacological effects, that is, compounds represented by the general formula (1) or salts thereof: (1) wherein X1-X2 is S-CH2 or the like; R1 is alkyl or the like; p is 0 to 7; R2 is hydrogen, alkyl, or the like; R3 is hydrogen, alkyl, or the like; Y1-Y2 is CH=CH or the like; R4 is halogeno, alkyl, or the like; q is 0 to 4; and R5 is halogeno, hydrogen, alkyl, or the like.