1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetrakis(1,1-diMethylethyl) ester, commonly known as DOTA-tert-butyl ester, is a versatile chelating agent in the medical field. It is characterized by its ability to form stable complexes with various metal ions, which makes it an essential component in diagnostic imaging procedures such as MRI and PET scans. DOTA-tert-butyl ester is also recognized for its role in targeted cancer therapy and drug delivery systems due to its selective binding to tumor cells and its capacity to carry therapeutic agents. Its high stability and low toxicity further contribute to its value in the development of innovative pharmaceutical and biomedical applications.
585531-74-4
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Basic information
- Product Name: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetrakis(1,1-diMethylethyl) ester
- Synonyms: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetrakis(1,1-diMethylethyl) ester;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7,10-tetrakis(1,1-dimethylethyl) ester;BFCAs-1
- CAS NO:585531-74-4
- Molecular Formula: C32H60N4O8
- Molecular Weight: 628.8408
- EINECS: N/A
- Product Categories: N/A
- Mol File: 585531-74-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 628.9±55.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.038±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 5.83±0.20(Predicted)
- CAS DataBase Reference: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetrakis(1,1-diMethylethyl) ester(CAS DataBase Reference)
- NIST Chemistry Reference: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetrakis(1,1-diMethylethyl) ester(585531-74-4)
- EPA Substance Registry System: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetrakis(1,1-diMethylethyl) ester(585531-74-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 585531-74-4(Hazardous Substances Data)
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585531-74-4 Usage
Uses
Used in Diagnostic Imaging:DOTA-tert-butyl ester is used as a chelating agent for metal ions in diagnostic imaging procedures such as MRI and PET scans. Its ability to form stable complexes with metal ions enhances the imaging contrast and allows for better visualization of internal structures and potential abnormalities.
Used in Targeted Cancer Therapy:
In the field of oncology, DOTA-tert-butyl ester is utilized as a targeting moiety in cancer therapy. It selectively binds to tumor cells, facilitating the delivery of therapeutic agents directly to cancerous tissues. This targeted approach minimizes damage to healthy cells and enhances the effectiveness of treatment.
Used in Drug Delivery Systems:
DOTA-tert-butyl ester is employed in the development of drug delivery systems to improve the efficacy and bioavailability of therapeutic agents. Its high stability and low toxicity make it an ideal candidate for the design of novel drug carriers, which can protect the drug from degradation and release it at the desired site of action.
Used in Pharmaceutical Development:
The unique properties of DOTA-tert-butyl ester, including its metal chelation capabilities and compatibility with various therapeutic agents, make it a valuable component in the development of new pharmaceuticals. It can be incorporated into drug formulations to enhance their performance and expand their applications in medicine.
Used in Biomedical Applications:
Beyond its use in medicine, DOTA-tert-butyl ester also finds applications in the broader field of biomedical research and development. Its ability to bind metal ions and its stability make it suitable for use in various biotechnological and diagnostic tools, contributing to advancements in healthcare and life sciences.
Check Digit Verification of cas no
The CAS Registry Mumber 585531-74-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,8,5,5,3 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.Calculate Digit Verification of CAS Registry Number 585531-74:
(8*5)+(7*8)+(6*5)+(5*5)+(4*3)+(3*1)+(2*7)+(1*4)=184
184 % 10 = 4
So 585531-74-4 is a valid CAS Registry Number.
585531-74-4Upstream product
585531-74-4Downstream Products
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1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tetrakis(1,1-diMethylethyl) ester
