585540-89-2Relevant academic research and scientific papers
TRI-SUBSTITUED 2-BENZHYDRYL-5-BENZLAMINO-TETRAHYDRO-PYRAN-4-OL AND 6-BENZHYDRYL-4-BENZYLAMINO-TETRAHYDRO-PYRAN-3-OL ANALOGUES, AND NOVEL 3,6-DISUBSTITUTED PYRAN DERIVATIVES
-
Page/Page column 24; Sheet 2, (2008/06/13)
Novel 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of anti- depressants.
Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters
Zhang, Shijun,Zhen, Juan,Reith, Maarten E.A.,Dutta, Aloke K.
, p. 6301 - 6315 (2007/10/03)
Structure-activity relationship study of cis-(6-benzhydryl-tetrahydropyran- 3-yl)-(4-fluorobenzyl)-amine derivatives and their bioisosteric analogs for the monoamine transporters in the central nervous system. In our effort to delineate novel pharmacophor
Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter
Zhang, Shijun,Reith, Maarteen E. A.,Dutta, Aloke K.
, p. 1591 - 1595 (2007/10/03)
In our effort to develop novel molecules for the dopamine transporter, we converted our previously designed dopamine transporter specific 3,6-disubstituted piperidine template into corresponding pyran derivatives. cis-Pyran derivative 7b, like their piper
