5857-02-3

Upstream product

• 106-49-0 p-toluidine 
• 2327-67-5 N-(p-tolyl)-P,P,P-triphenylphosphine imide 
• 79-30-1 isobutyryl chloride 
• 6876-49-9 N-(4-methylphenyl)-2,2-dimethylacetamide 

Downstream Products

• 18779-86-7 dimethylketene-N-p-tolylimine 
• 78554-77-5 3-Isopropyl-2-p-tolyl-2H-[1,2,4]thiadiazol-5-ylideneamine; hydrochloride 
• 99164-27-9 thallium [1-(p-tolylimino)-2-methylpropyl]cyclopentadienide 
• 78554-82-2 2,6-Diisopropyl-3,5-di-p-tolyl-3,5-dihydro-4λ⁴-[1,2,4]thiadiazolo[5,1-e][1,2,4]thiadiazole 
• 78554-84-4 2-Isopropyl-6-(4-methoxy-phenyl)-5-methyl-3-p-tolyl-3,5-dihydro-4λ⁴-[1,2,4]thiadiazolo[5,1-e][1,2,4]thiadiazole 
• 78554-80-0 C₁₂H₁₅N₃ 
• 74366-33-9 2-Isopropyl-4,4-bis(4-chlorophenyl)-6-methyl-4H-3,1-benzothiazine 
• 74366-34-0 2-Isopropyl-4,4-ditolyl-6-methyl-4H-3,1-benzothiazine 
• 74366-29-3 2-Isopropyl-4,4-diphenyl-6-methyl-4H-3,1-benzothiazine 

Relevant academic research and scientific papers

Innovative synthesis of 4-carbaldehydepyrrolin-2-ones by zwitterionic rhodium catalyzed chemo- and regioselective tandem cyclohydrocarbonylation/CO insertion of α-imino alkynes

The tandem cyclohydrocarbonylative/CO insertion of α-imino alkynes employs CO, H2, and catalytic quantities of zwitterionic rhodium complex (η6-C6H5 BPh3)-Rh+(1,5-COD) and triphenyl phosphite affording aldehyde substituted pyrrolinones in 67-82% yields. This unique transformation is readily applied to imino alkynes containing alkyl, alkoxyl, vinyl, and aryl substituents. The ability to prepare highly functionalized pyrrolinones makes this an attractive route to these important and versatile pharmaceuticals.