58570-06-2Relevant articles and documents
Reactions of 2 acyloxyisobutyryl halides with nucleosides. VI. Synthesis and biological evaluation of some 3' acyl derivatives of 2,2' anhydro 1 (β D arabinofuranosyl)cytosine hydrochloride
Hamamura,Prystasz,Verheyden,Moffatt
, p. 654 - 662 (1976)
The reactions of cytidine with 22 different 2 O acyloxyisobutyryl chlorides lead to the isolation of the corresponding 2, 2' anhydro 1 (3' O acyl β D arabinofuranosyl) cytosine hydrochlorides. These compounds, which all show cytotoxicity against HeLa cell
Metal-Free Photoinduced Hydroalkylation Cascade Enabled by an Electron-Donor-Acceptor Complex
Correia, José Tiago M.,Piva Da Silva, Gustavo,Kisukuri, Camila M.,André, Elias,Pires, Bruno,Carneiro, Pablo S.,Paixa?, Márcio W.
, p. 9820 - 9834 (2020/09/03)
A metal- A nd photocatalyst-free photoinduced radical cascade hydroalkylation of 1,7-enynes has been disclosed. The process is triggered by a single electron transfer (SET) event involving a photoexcited electron-donor-acceptor complex between an NHPI ester and a Hantzsch ester, which decomposes to afford a tertiary radical that is readily trapped by the enyne. The method provides an operationally simple, robust, and step-economical approach toward the construction of diversely functionalized dihydroquinolinones bearing quaternary centers. A sequential one-pot hydroalkylation-isomerization approach is also offered, giving access to a family of quinolinones. A wide substrate scope and high functional group tolerance were observed in both approaches.
NOVEL COMPOUND AND MEDICAL USE THEREOF
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Paragraph 0359-0360, (2013/09/26)
Provided is a levodopa prodrug that overcomes the problems attributed to the blood kinetics of levodopa such as large number of doses and the incidence of side effects due to frequent dosing. (2S)-2-Amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)p