58576-03-7Relevant academic research and scientific papers
From styrenes to enantiopure α-arylglycines in two steps
Laxma Reddy,Barry Sharpless
, p. 1207 - 1217 (2007/10/03)
Direct enantioselective synthesis of (R)- and (S)-N-Cbz- or N- BOC-protected α-arylglycinols from styrenes via catalytic asymmetric aminohydroxylation, with enantioselective up to 99% and isolated yields up to 80%, is described. In a subsequent oxidation step, these glycinols yield the corresponding carbamate-protected α-arylglycines.
